ࡱ> Y RJbjbj[[Ep9 \9 \6)X X 8'YOO"qqq"X$X$X$X$X$X$X$[W^HX9HXqq4X<(((qq"X("X((n0GIq~i$@H XXHY`H=_%5e@II&=_e$J(HXHX'$Y5eX I : -NVwm m'Yf[,gyu z'Y~ z Tyoirf[Drug Designology  zNx100102201207 z^\'`NNwƋe/f[R32/2 z'`( O[f[e0#NYe^NgSfhg _lYOzy _!fYf[e0 z^\'`lQqQW@x/ƋYe/f[yW@x/NNwƋ/]\Ob z'`(_O0 O zN~ 1. zc-Ne  oirf[/fNoirSs@bmSvu}Tyf[vW,gSt:NW@x ͑pReoxvz@bvoirvW,gelSoirSseb/gTeWvN蕰etQf[y0,g z\NWNvpvoir0WN~gvoirSWN'`(voir N*Neb|~U\_ NWNOSl[0vOSt08hxSt0SSOMSO~g0N"St0uir5uP[I{cSO0RP[BgTStvoirI{:N;NQ[ f Y7h'`N[{  T Ttoir voirxvz!j_0 Drug Designology is a new subject which focuses on the basic principles of drug design in the researchanddevelopmentofnew medicaments as well as new technologies and fields in drug discovery. Drug Design is based on the knowledge of relevant bioscience. This course can be divided into three major parts including Target Based Drug Design (TBDD), Structure Based Drug Design (SBDD) and Property Based Drug Design (PBDD), which mainly describes the theory of drug design based on signal transduction, enzymatic reaction, nucleic acid, structure of receptor and ligand, drug metabolism, bioisosterism, and molecular hybrid, and finally interprets the research mode of  diversity design and biological evaluation an  rational drug design . 2.` яNASt^eg @w~TSf[Nؚϑ[{ 0u}Tyf[0~guirf[0{:gRoirI{b/gvŏsSU\ oirSsvǏ zck(WnN:g0vP6qSsekT~gY7h'`SsTTtoirlS mvNoirSs0RHQ[STirOShQǏ zvoirf[_N]NoirSf[vNRnoSb|~T[YvNf[y0[boirSf[ zvf[`NKNTYg NۏNekf[`Noirf[vvsQi_0b/gTel HNf[u NNNtS_NoirvSU\S _NN܀NNTNNveoxS]\O Vdk oirf[ zvn(Wof[ReWNMbvW{Q NwQ g_'`0R'`TSL'`0 (WYef[Q[vc N \ cgqWNvpvoir0WN~gvoirTWN'`(voirwQSOU\_ gevoirvW@xTt \TtvoirN~TSf[b/gv~T NSSOt0vb6RBR0N"bbt0uir5uP[I{ct0MRoStI{0oirf[/fNck(W_SU\vf[y Vdk,g z(WtwƋv Te _N\~TS_Noir_SvwQSOO Of[u[,gf[yMRlwƋToirxSvW,g_Tel gf|~vƋ0 3. zNvQN zvsQ| oirf[Q[mS0RoirSf[0RP[uirf[0uirSf[0oNRRf[0{:gRoirI{OYwƋSO| :NNSf[y0 1 HQL zoirSf[0RP[uirf[0uirSf[ 2 v^L zoNRRf[0{:gRoir zvh ,g z/f O~voirSf[ zv^8O [boirSf[ zvf[`NKNTۏNekf[`Noirf[vvsQi_0b/gTel,\ gRNf[utS_NoirvSU\SNSoirxSvS z [W{Qf[utQ0oSRe`~0:NNTyx]\O[`Y[W@x,[NReWNMbW{QwQ g͑aIN0 1 Ǐ,g z f[u\N㉰eoxvzT_S z^0q`eoHQ[STir vSs_0ccoirvW,gStTel0 2 @w͑N~eoSsveStTeb/g Of[uǏ[Ǐ zvt0wƋvmST]v$Re nW{Qrz`TR RǏ~T~TSf[T{:gRoirvMRlWv _bf[uƉΑ0/TNNv`~0Rm[,gf[yvƋkbqvoirvStTel \ g)RNf[u:NNTvyxSNNvsQW]\OSb NNb[vW@x0 3 (W`?eYe N W{QwQY1rV``0j`[of[LNS_0 gRN>yOTwQ gRe|^ySrz`Rvof[NNWNMb0 N0f[`NBl :NOf[u0RgsOvf[`Nbg [f[uvBlY N 1 cMR`N zQ[ ce N, Nw,T ygSNX0 cecNX\ONTKmՋ0XhsTQRs/fb~8hv~bR0 2 ce[bs^e\ON0KmՋI{ zNR0f[u cfNbb__bQ~b__cN Blrz[b Q[{SOsf[u[vrz` N_bvQN Tf[S Y6R|4N-NvQ[ ^gcNcMR_0RNYe^vS0 3 [bYe^^nvN[ϑvYe.sT̀ofDe0MRlOmȉI{NR (W zۏLǏ z-N\[cf[u[YQ[ۏL;`~0R_~v^ۏLYZSOU\:y0YOf[uRm[ zQ[vƋ0;phR0Oۏ Tf[vNf[`N0v^_[[gNwƋtvmeQ`0 V0Yef[ۏ^ ^SN;NRe;NQ[i[[ Q[ bY~`NI{1oirf[~1oirf[vNRTQ[oirSsv_0TtoirvtTwƋ0cPoirf[YePgTSfN cPCgZBg_Sof[8^(uQ@W0Qz0&(JTVX`bz|~л}rgr`}r}rXOXChOUh`ICJPJo(hICJPJo(hICJPJ hU2h`IhIhICJPJhOUh`ICJPJhOUh`ICJPJQJhZ h`ICJPJhGCJPJhZ hICJPJ%hDh`IB*CJOJPJQJph(hDh`IB*CJOJPJQJo(phh`IKHOJPJQJaJ h`IKHOJPJQJaJ o(#hl3h`IKHOJPJQJaJ o((Xb|$d$Ifa$gdg=$d$Ifa$gdELS$d$Ifa$gd`I $1$a$gd`I|~^O@OO$d$Ifa$gdELS$d$Ifa$gdg=kd$$Ifl\ "!0!44 lalytE ^O@OO$d$Ifa$gdELS$d$Ifa$gdg=kd$$Ifl\ "!0!44 lalytE ĵsgZKhELSh`ICJOJPJQJh`CJOJPJQJo(h`CJOJPJQJhELShICJOJPJQJo("h`IB*CJOJPJQJo(phhICJPJhOUh`ICJPJhOUh`ICJPJQJhfah`ICJOJPJQJhrCJOJPJQJo(%hDh`IB*CJOJPJQJph(hDh`IB*CJOJPJQJo(ph hU2h`I^O@OO$d$Ifa$gdELS$d$Ifa$gdg=kdp$$Ifl\ "!0!44 lalytE N X t  ^PHC:b`bgd\gd?6 & F gd=b] dWD`gd`Ikd($$Ifl\ "!0!44 lalytE  L N R V X Z \ d n p r t лxhXKX6$"hB*CJOJPJQJo(ph(hm9 hB*CJOJPJQJo(phhLp0CJOJPJQJo(hm9 hCJOJPJQJo(hLp0hl`CJOJPJQJo(hLp0h`ICJOJPJQJo(h5CJOJPJQJo("h8hP5CJOJPJQJo("h8h^5CJOJPJQJo()hOUh`IB*CJOJPJQJaJph,hl,h`IB*CJOJPJQJaJo(ph/hl,h`I5B*CJOJPJQJaJo(ph t $ T    $ , ^ ﰠqeqVGh!?ha@B*CJPJphh!?hrB*CJPJphh ?B*CJPJphh!?h\B*CJPJphh\h*CJOJPJQJo(h\h>BCJOJPJQJo(h\hCJOJPJQJo(h\h8(yCJOJPJQJo(h\hICJOJPJQJo(h\hICJOJPJQJh\hO_CJOJPJQJo(h\hQ\CJOJPJQJo( E R U [ ^ ) + O ٽٮٟsfV>.h8hUtPhUtPB* CJOJPJQJo(phhm9 hCJOJPJQJo(h`ICJOJPJQJo(h!?h\B*CJPJphhZ B*CJPJo(phh!?h^B*CJPJphh!?h 1B*CJPJphh!?hrB*CJPJphh!?hO$B*CJPJphh!?ha@B*CJphh!?ha@B*CJPJph.h!?ha@B*CJPJfHphq  j(XbZx< gd\#gd#5 WD`gd#5gdNSgdBq bWD`bgd & F gdv\}`gd6gd=b]`gd\gd?6 bWD`bgd*zL ڰs^I4^(h!?h/!B*CJOJPJQJo(ph(h!?hF*B*CJOJPJQJo(ph(h!?hB*CJOJPJQJo(ph(h!?hB*CJOJPJQJo(ph%h!?h>BB*CJOJPJQJph(h!?hNB*CJOJPJQJo(ph(h!?h<<B*CJOJPJQJo(ph(h}GhzB*CJOJPJQJo(ph(h!?hzB*CJOJPJQJo(phh TB* CJOJPJQJph .>@Xfhjnp֬oZGZGZG2(h!?hB*CJOJPJQJo(ph%h!?h/!B*CJOJPJQJph(h!?h/!B*CJOJPJQJo(ph#h=b]B*CJOJPJQJ_H ph,h\h=b]B*CJOJPJQJ_H o(ph&h=b]B*CJOJPJQJ_H o(ph(h!?hB*CJOJPJQJo(ph(h!?hwwB*CJOJPJQJo(ph(h!?hB*CJOJPJQJo(ph(h!?hyB*CJOJPJQJo(ph&(.08VX\`bjnx|~°m]N]m]m]m]m?hCJOJPJQJ\o(h ?CJOJPJQJ\o(hhCJOJPJQJ\"hhCJOJPJQJ\o("hhv\}CJOJPJQJ\o(hv\}5CJOJPJQJ"h8hk45CJOJPJQJo("h8h.5CJOJPJQJo((h!?h/!B*CJOJPJQJo(ph(h!?hB*CJOJPJQJo(ph%h!?h/!B*CJOJPJQJph68Z` <̺̘zfUFUFfhW CJOJPJQJ\^J hW CJOJPJQJ\^Jo(&h\h#5CJOJPJQJ\^Jo(h6CJOJPJQJ\o(huHCJOJPJQJ\o("h\h#CJOJPJQJ\o(h\hBqCJOJPJQJ\"h\hBqCJOJPJQJ\o("h\h#5CJOJPJQJ\o(hhCJOJPJQJ\"hhCJOJPJQJ\o(<>vxz|lnLɷwkw^w^wQ^D^w7hCJOJPJQJo(h6CJOJPJQJo(hCCJOJPJQJo(hCCJOJPJQJo(h#5CJOJPJQJh#5CJOJPJQJo(hQ95CJOJPJQJo("h8hO>l5CJOJPJQJo("h8hQ95CJOJPJQJo("h8h>>μ{{hShShShShShQShU(hhB*CJOJPJQJo(ph%hhB*CJOJPJQJphh Sh5B*CJph#h Sh5B*CJQJo(phh5B*CJQJo(ph h Sh5B*CJQJph"h\h=b]5CJOJPJQJo(hl`5CJOJPJQJo("h8h5CJOJPJQJo(h\h=b]CJOJPJQJo( &4>DRTXZjn>> >4>L>P>>>>>>>Ff FfFfI $$G$Ifa$gdoirvxSS z/f`7hv2WNvpvoiroirvu}Tyf[W@x3oir\O(uvuirvp R{|oirNuir'YRP[vpvvN\O(uoir-SSOvN\O(uvSf[.{|+RSyrp3WNOSl[voir2~ހOSRP[N~ހSSO~ހOSl[voir~ހQOSl[voirvgeۏU\4WNvOStvoir2vOS^Tvb6RBRvTtvb6RBR{|oirWN~g:g6Rv^qQN.~Tvvb6RBRvR{|SvQyrp5WN8hxStvoir28hxuirN"TbStvoir;NV{eu8h{|oirv~gyrpR>N5*N8h{|vb$vbbukvoir RgvQSt6WN~gvoirWNSSO~gvoir2WNvp~gvTtoirRP[[cNZb[{ WNGrkvoirvW,g`TxvzAm zNHN/f{:gZb[{ 7WNMSO~gvoir2WNMSO~gvoirvW,gi_oHeV!jWSvQ^(uWNMSO~gv{:gRoirRP[vi_SvQxvzQ[ gTN8WN'`(voir{|o'`SvQ(Woir-Nv^(u4oir(WSOQvǏ z_woirk'`v:g6R{|o'`SvQċNelT^(uYUO_U\STir{|o'`ċN9WNuir;m'`voir2{|vW,gi_0StTel{|(Woir-Nv^(u{|v;NelTV{eu10WNN"Stvoir2oirvN"NeoMRo0oo0vTMRoV{euMRov8h_``0;NelTV{eu11WNuir5uP[I{cStvoir2uir5uP[I{cSOR{|uir5uP[I{cSO(Woir-Nv^(ume toooirvV{euuir5uP[I{cSOvR{| >NOfuir5uP[I{cSO(Woir-Nv^(u12WNRP[BgTStvoir2RP[BgTStj[ovV{euNЏ(uYvpoirvV{euNЏ(u>NOfYvpoir(Woir-Nv^(u13WN~TSf[voir2~TSf[vi_SStWN~TSf[b/gvoirSؚϑ[{ ~TSf[^vg^elNb/g~TSf[xvzv8h_``TW,gStS~TSf[^(uvW14eo_SvW,g_Tel2oirvhvSsHQ[STirvSsSOS4N^P oirvxvzN_SHQ[STirSsT~gOSv;N_Tel15ReoirxS[O2ReoirvxSXblf<\0"}^^ge.s bN*NoirRgvQ(WHQ[STirOS-N^(uvoirV{eu N0SYePgN;NSfN (uYePg 0oirf[ 0,{3Hr eim;N NlkSuQHr>y 20160 20;NSfN 1 0oirf[ 0,{3Hr S_R;N ؚI{YeQHr>y 20150 2 0oirRP[ 0 퐗[Q;N yf[QHr>y 20050 3 0{:gRoir[ 0,{2Hr NO0S_R;N Sf[]NQHr>y 20170 4 0oirf[f[`Nc[N`NƖ 0,{2Hr hgSfy;N NlkSuQHr>y 20160 mQ0b~ċ[ N 8he_ A A.wSՋ B._wSՋ C.e D.g E.vQN N b~~TċRSO| b~~TċRSO|kO%1. N\ON0XSs^8^hs20%2.s^eKmb~20%3.g+gՋb~60%;`100%N0f[/gڋO f[`Nbg N GP YՋ\O _0vSNNf[`Nbg0NNbJT(uN N Tv zI{ GW^\ GPL:N0NNv`l0lTaY NlfQY cv(uY0,g zY gSs N NoL:N \ cf[!h gsQĉ[Sm,g zvf[`Nb~0 kQ0'Y~[8h Yef[b bf[/gYXTO~{z     PAGE  PAGE - 6 - >>>J>P>>>>>>>>>8?:??Z?^???????b@d@f@h@@@A A AA(A*A.AAAAAAA:BB@B^BbBBBBBBB>C@CBCFCjCnCCCDDݻݻݻݻݻȦݻݻݻݻ(h hB*CJOJPJQJo(phh ShB*aJph(hhB*CJOJPJQJo(ph%hhB*CJOJPJQJphh ShB*QJaJphA>>?:?BBBDB^BbBBBBBBBFf%Ff!Ff% $$G$Ifa$gd $$G$Ifa$gdBBC@CBCHCJCjCnCCDDDD,D0DpDDDDDDDETEVEFfm4Ff0Ff-FfM) $$G$Ifa$gdDD D,D0DDDDDDDTEVEZExE|EEEEE FFrFtFvFxFzF|FFFFFFF򸤐|hUhU$h!?h B*CJOJPJ\ph'h!?h B*CJOJPJ\o(ph'h!?hm9 5B*CJOJPJo(ph'h!?hp5B*CJOJPJo(ph'h!?h5B*CJOJPJo(ph"h=b]h=b]5CJOJPJQJo((hhB*CJOJPJQJo(ph%hhB*CJOJPJQJphh ShB*aJph!VE\E^ExE|EEEEEE FF2FtFvFxFFFFF8GtG$a$gd\$a$gd $ & F ^`a$gd $a$gdNSgdNSFf;Ff8 $$G$Ifa$gdFFFFFFG G2G4G6G8G>GjGpGrGtGzGGGGGGGGGH"H$H&Hڳ렍ڍzizizzXz!h!?h\B*CJOJPJph!h!?h2B*CJOJPJph$h!?h2B*CJOJPJo(ph$h!?h\B*CJOJPJo(ph$h!?h B*CJOJPJ\ph'h!?h\B*CJOJPJ\o(ph$h!?h B*CJOJPJo(ph!h!?h B*CJOJPJph'h!?h B*CJOJPJ\o(phtGG&H4HHHHHHPkd>$$Ifl:0U"7 t0644 lagAytLD $$Ifa$gdW WD`gdqP WD`gd $a$gd\&H(H*H2H4H:HBHFHHHLHNHPHRHZH^H`HhHlHnHrHvH|HHHHHHѻyly_R_R_R_R_REhl3CJOJPJQJo(h`IWCJOJPJQJo(hWICJOJPJQJo(h2>*CJOJPJQJhXnW>*CJOJPJQJo(h h CJOJPJQJo(hXnWCJOJPJQJo(+h!?h=b]5B*CJOJPJQJo(ph+h!?hPc5B*CJOJPJQJo(ph+h!?h^5B*CJOJPJQJo(ph/h!?hm9 5B*CJOJPJQJaJo(phHHHHHHHHHHHHHHHHHHHH˾xk[K?2Kh2CJOJPJQJo(h2CJOJPJQJhLDh_SCJOJPJQJo(hLDhFCJOJPJQJo(hWCJOJPJQJo(hFCJOJPJQJo(hl3h:|CJOJPJQJo(1hl3h_Sh_S5B*CJOJPJQJo(phh h CJOJPJQJo(h00KCJOJPJQJo(h_SCJOJPJQJo(hpCJOJPJQJo(hXnWCJOJPJQJo(hm9 CJOJPJQJo(HHHHHIe\ $IfgdqPkd>$$Ifl:0U"7 t0644 lagAytLD $$Ifa$gdF $Ifgd00KHHHHIII IIIII I*I0I2I6I8IBIDIIIJﭛmNm<h8hCJKHOJPJQJ^JaJfHo(q <h8hCJKHOJPJQJ^JaJfHo(q h:|5CJOJPJQJo("hh5CJOJPJQJo(hm9 5CJOJPJQJo(hXnWCJOJPJQJo(h2CJOJPJQJo(h2CJOJPJQJhpCJOJPJQJo(hLDh_SCJOJPJQJo(III"Izqe $$Ifa$gdF $IfgdqPkd-?$$Ifl:0U"7 t0644 lagAytLD"I$I*I4Iznn $$Ifa$gdFkd?$$Ifl:0U"7 t0644 lagAytLD4I6IDIJzJ|JJJJJJzuj_ZXXXXXgdC WD`gdC WD`gdF]7gdUtPkdY@$$Ifl:0U"7 t0644 lagAytLD JJJJ&JfJhJxJzJ|J~JJJJJJJJJJJJJJJJ˾}}}}smsmiTDTh Fhlr0JCJOJaJo((jh Fhlr0JCJOJUaJo(hlr hlr0Jjhlr0JUhCkjhCkUh5 h /CJOJPJo(-hm9 5B*KHOJPJQJ^JaJo(phDDDh hWCJOJPJQJo(hUtPCJOJPJQJo(h5CJOJPJQJo(hm9 5CJOJPJQJo(+h8hCJKHOJPJQJ^JaJo(JJJJJJJJJJJJgdC$&#$a$gd2y hh]h`hgdF &`#$gd F JJJJJJJh5 h /CJOJPJo(hCkhlrh Fhlr0JCJOJaJo((jh Fhlr0JCJOJUaJo(!hE 0JCJOJaJmHnHuC09&P 0p1C2P:p. A!4"#$% $$Ifl!vh#v#v#v#v:V l0!,5555/ alytE $$Ifl!vh#v#v#v#v:V l0!,5555/ alytE $$Ifl!vh#v#v#v#v:V l0!,5555/ alytE $$Ifl!vh#v#v#v#v:V l0!,5555/ alytE g$$Ifl!vh#v#v#v#v*#vA #v:V lp  t<06,5555*5A 5` alp<yt.kd$$IflpֈT M"*A   t<0644 l` alp<ytg$$Ifl!vh#v#v#v#v*#vA #v:V lp  t<06,5555*5A 5` alp<yt.kdy$$IflpֈT M"*A   t<0644 l` alp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd $$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd $$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd:$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kdb $$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd$$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd'$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kd+$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<yty$$Ifl!vh#v#v#v#v*#vA #v:V l4p  t<06+,5555*5A 5` algX:Gp<yt;kdB/$$Ifl4pֈT M"*A   t<0644 l` algX:Gp<ytq$$Ifl!vh#v#v#v#v*#vA #v:V lp  t<06,5555*5A 5` algX:Gp<yt8kd2$$IflpֈT M"*A   t<0644 l` algX:Gp<ytq$$Ifl!vh#v#v#v#v*#vA #v:V lp  t<06,5555*5A 5` algX:Gp<yt8kd6$$IflpֈT M"*A   t<0644 l` algX:Gp<ytq$$Ifl!vh#v#v#v#v*#vA #v:V lp  t<06,5555*5A 5` algX:Gp<yt8kdT:$$IflpֈT M"*A   t<0644 l` algX:Gp<yt$$If!vh#v7#v:V l: t06575gAytLD$$If!vh#v7#v:V l: t06575gAytLD$$If!vh#v7#v:V l: t06575gAytLD$$If!vh#v7#v:V l: t06575gAytLD$$If!vh#v7#v:V l: t06575gAytLDi[Ci[Cԁ;AlK@y^i[Ci[Ci[Ci[Cԁ;AlK@y^i[Ci[Ci[Ci[Ci[Ci[Ci[Cԁ;AlK@y^i[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[C%s002 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@PJ_HmH nHsH tHN`N hcke $1$a$$CJ KHPJ_HaJmH nHsH tHRR wh 1$$dBTJ@&5CJ,KH,PJ\aJ,ff wh 2$$7$8$@&H$^`a$ KHOJPJQJ^JaJ mHsH$A`$ ؞k=W[SOBi@B nfh-\".B-?7}>FTlon77Ԝx?|+NST2 XiEꭶ?j]m^_^+P[wD+PW-W_YW ͶW5 R ~,VAFXuVKsKTCV]rŦZ-t  ;b6#42% qv8›q. B˟TDFLڐAB&~ ^] ُ=q==~NV;(VG:=ՃxiJ!x?>~?< }a\G5TLx?y;~nьHbwc:EGP~Ds |w<4rg!Rt|+c m߆6Il!Q] sZ;aQITjYV`<$6D='Ienb~k3MHýS^P\wr^+j~k~vt~t«(:zQk_۶sWb/?ѹS)uzݜnrʵ+Am~޽: 5ˁWrbJAүsUTjzf5η1T>汀*^PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!.theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] `4p (((+t <>DF&HHHJJJ &*,./157| > ABVEtGHI"I4IJJ'()+-02346 $+! !@ @H 0(  0(  B S  ? *,0DFIKLNUYZ\]ajmruvz~~kprs8CDI,05JOPUir<=CD`bn~ ~   " > @ C E X Z f h    - 6 E G q s   & ) * E G Z e h j   0 2 I T W Y 45AEGHOPQRefhist{|}~    !%(,/1469;=>JLSUZ\pt~ +,689;<>?ABM[^a~~8A H K   UV689;<>?AB^a3333ssDIZ]~~<C~    U X d f + 7 C E ~   ' ) V Z f h   E I U W AG <JXiklvwyz5689;<>?AB^a%*~~, ""$$ 566899;<>?AB^a (= ADzKP z2j 8=Rt/t6XTH%Mz=E!D"TJm3`3>{2>Cluz)e8LtP  VE -r : & + m9 @ P W 8 ^ rt 8  c * 6 !P -'@F0b Z sR3Qm5RnC^MR5qP,"b5Nl` L e#%Ru<`cc{ (]f`>M&+A.No ^%8NNzF*L^$,6q@NAi\ph#j~Z$%5dI : T Z ~m 9!%!/!"Lj#V$EC$ I$$%j'%f_%$&L&&'('$<'1(8(X(+)m)v**Q*v*+A++q+ .J.1N.g.bt.V// /#/b/X0mD0^0Lp0t0n1.1P1R1W1e1w1!2U2DX2f2>3l3v34$4Q4]445 555mN5 6?6A6H6"f6(j67\ 7P7F]7{88 88n-9Q9}91:C:p:N;)g;&<1r<Lx<G> ?!?E?r? @,@T6@$E@AZ@h@Sm@ A AB A,A,A8ANAbAB>BFBOBU`BwB=4CZC|fCuCLDh]D}DE:EaEJcE F$F-FGFRUFaF2GGHoHuH; I'IhqBhLh6[h^i io#i9iciNpij1jTkYk]k<lcl@mNQmnenWnHJoQop$p]pvpBqwq~qCrr r[r|r s#+s _s2tt{7tHt^tSufu|uvp$v[JvwvBwVYwvlwnww2x x/x2Ix2yG$y8(yCyTzgz@z.[zIz {k!{$"|W%|'|e|! } }v\}e}g}~^~m~ ,@ uv~-N{UZfA~-0i|(q0/KS3a15KSS4' ]ky8z <%GPPazn: Ak U|G %08]B7Y!l i:r&m NW&.ISTMcz5 .B[*v@EE8NEmJFAOyuMC l,]c~LNZ_ #6' 1~p{YZQaT'}TX5gilrOw{ ;/)S^yN"#>sRU^tKO^bFfW QXb V\Q s : RM ch'$Zg=5A!ZbkWz&$4LH\Ijv UTfaww8\N.RI[;pp!PelD#5OZ^]s J9K#<9\kn'W)/;TYx Dg)O$23FJdQz/$S1Ic+h AGNSK]q5mon!`JjhC`UBHMKR~MWqk!5Z<?J`x(.A=Zy1'-frs|a@N! 'l>}O7<>PWCkucUi5])`I k%CF1X9 r8oy AMg/?7fx VxM?O{^ *;E=XsGIJ>Ndwx}{//8KTNiu]+-@djnc NRp + k4j?nGn D8MR'<Z(Wm<<sUoI1A_`{#$9CVzq O_fUnknownuser Administrator G*Ax Times New Roman5Symbol3. *Cx Arial;= |8ўSOSimHei;([SOSimSun5. .[`)TahomaA5  N[_GB2312N[?= *Cx Courier New7. [ @Verdana;WingdingsA$BCambria Math 1h܈WT&:k k -!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[4d=2.. 3qHP ?JcE2! xx JC:\Documents and Settings\new\Application Data\Microsoft\Templates\s^Le.dot XntLb020060S_o(u7b_o(u7b*DFZjnr-rn DNS|~-/fDQ`~& AHRehprt~ kya@@AA/A?AOA_AoAAAA4ATAAAAABB(/B?BOB_BoBBBB6BBBB B B CCW/C?COC_CoCCCCCCCCCCDD/D?DOD_DoDDDDDD i Z'`IZ'@         Oh+'0  4 @ L Xdlt|ְԺ2006 ΢ûƽ ΢û5Microsoft Office Word@܃+@_g@Z|@~k ՜.+,0 X`t|  ΢й.   !"#$%&'()*+,-./012345678:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry F`~Data 9D1Table\ueWordDocument EpSummaryInformation(DocumentSummaryInformation8MsoDataStore@~~MWZFQJ0OMMFA==2@(~~Item  PropertiesUCompObj n   FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q