ࡱ> e RibjbjJJE(_b(_b) [[[[[ooo8KloV"    V V V V V V V$Y?\0V9[     0V[[4iV<5*5*5* [[ V5*  V5*5*6FpH0C %FUVHVG`5]&^8pHpH&5]^$[H`  5*     0V0V](   V    ^          Q !: -NVwm m'Yf[,gyu z'Y~ z TyuiroBRf[NoirRRf[ Biopharmaceutics and Pharmacokinetics zNx100104201201 z^\'`]\Obe/f[R32/2 z'`( O[f[e#NYe^hg=rYf[e64 z^\'`lQqQW@x/ƋYe/f[yW@x/NNwƋ/]\Ob z'`(_O0 O zN~ 1. zc-Ne  uiroBRf[/fsQNoir6RBRbBRW(uNu}T g:gSOb~~ vf[yoirRRf[/fxvzoirSOQǏ zR`SSĉ_vf[y0,g z;NN~uiroBRf[NoirRRf[vW,gi_0W,gtSW,gSt SbS gS^S goirv8T6e oirvR^0N"TclǏ z oirRRf[-NvUS[!jW0Y[!jWSYBRϑ~o ^~'`oirRRf[ToirRRf[xvz-Nv~wRg oirRRf[NoHeRRf[vvNsQ| NSoirRRf[(Weo_S-Nv^(uI{0Ǐ,g zvYef[ :Nf[ukNTNNoirf[ToirRRf[ebvxvzN_S`Y[NNb/gW@x0 Biopharmaceutics is a discipline about the use of pharmaceutical preparations or formulations in living organisms (or tissues). Pharmacokinetics is a discipline that studies the fate of drugs and their dynamic rules in vivo. This course mainly introduces the basic concept of biopharmaceutics and pharmacokinetics and their basic theory and basic principle, including the absorption of oral drugs and non-oral drug, the distribution, metabolism and excretion of drugs, the single compartment model, the multiple compartment model, the pharmacokinetics of drugs after multiple dosing, the nonlinear pharmacokinetics and statistical moment theory, the relationship between pharmacokinetics and pharmacodynamics, the application of the pharmacokinetics in the development of new drugs, and so on. This course is set up to lay a professional technical foundation for students to engage in the research and development of pharmacology and pharmacokinetics after graduation. 2.` Yef[v͑pQ[;N/f[TyuiroBRf[vW,gi_0W,gt oirv8T6e0R^0N"TclǏ zSyrpoirRRf[vW,gi_0W,gt US[!jW Y[!jWSYBRϑ~ovyrpNS^~'`oirRRf[ToirRRf[xvz-Nv~wRgoirRRf[NoHeRRf[vvNsQ| NSoirRRf[(Weo_S-Nv^(uۏLc0(WYef[Q[vc N cgqoir(WSOQvuirf[Ǐ zۏLN v^zcTyBRWv8T6e0R^0N"TclǏ zwQSOoirRRf[-NvUS[!jW Y[!jWSYBRϑ~o(WYef[el N 9hncf[u]wQYvutVRf[0uirSf[0oBRf[Totf[ebvW@xwƋ Ǒ(u/TS_Yef[el v^NYZSOYef[KbkegOۏf[u[wƋvhQbt㉌Tcc0 Te (WYef[-NT/UirlStTel0yf[|^yYeT``T_YeI{`?eCQ } '}ߍVEyxMRl Of[u|~hQbccvsQwƋb0 3. zNvQN zvsQ| uiroBRf[NoirRRf[vQQ[NutVRf[0oBRf[0otf[I{OYwƋSO|vNNS0͑poir6RBR(WSOQv8T6e0R^0N"TclǏ zv^^(uRRf[StxvzTKmoir(WSOQvTyǏ z0HQO zSbutVRf[0uirSf[I{NN z0vsQ zSbotf[0oBRf[0oirSf[0oirRg0 N0 zvh uiroBRf[NoirRRf[/fof[NN zv͑~bR ;Nvh/fxvzoir6RBR(WNSOQv8T6e0R^0N"TclǏ zv~T'`b/gyf[0Ǐ,g zvYef[ f[u\ccTy~o_voir6RBR(WSOQvYnǏ z EQRN㉨RRf[St(WoirSOQǏ z-Nv^(u {Qbyf[Rev`~e_ W{QRR[|^y wQ g1rV``0l6RaƋT>yO#Na :NNNoir6RBRvtxvz0NT_S0uNS(ϑ{tI{Sb NW@x0 N0f[`NBl 10cMR`N z ce N,w,T ygSNX0XKmՋTVT{0,g zXhsTQRs/fb~8hv~bR0 20Tw Y`N0;`~TR_~ v^~ToBRf[Totf[t zQ[0 V0Yef[ۏ^ ^SN b;NRe;NQ[i1,{Nz0uiroBRf[i21.ccuiroBRf[v[INNxvzQ[0 2.ccBRWV }NuirV }v+TIN0 3.q`uiroBRf[xvz(Weo_S-Nv\O(u0 4.NuiroBRf[vxvzۏU\02,{Nz S goirv8T6e41.ccuirv~gT'`(0lЏ_ 2.ccoirvlЏ:g6R0oirlЏSOvR{|0 3.ccq_Toir(WmSS8T6evTyV }0 4.ccuiroBRf[R{||~SvQ^(u0 5.q`ÀSv~g0R0 6.NS goir8T6evxvzelNb/g03,{ Nz ^S g~o_oirv8T6e 41.ccTy@{Yl\v8T6eǏ zSq_T8T6evV }0 2.ccoir~vT|8T6ev_Tq_T8T6evV }0 3.ccq_T8T6evV }0 4.q`ST0v0;T0v04STB*CJPJo(ph"hB*CJOJPJQJo(ph(hm9 hB*CJOJPJQJo(phhLp0CJOJPJQJo(hm9 hCJOJPJQJo(hLp0hl`CJOJPJQJo(hLp0h`ICJOJPJQJo(h5CJOJPJQJo("h8hP5CJOJPJQJo("h8h^5CJOJPJQJo(%h=b]5B*CJOJPJQJo(ph< @ ~  @ r  $ % / 0 3 U ` qeVEV hihB*CJPJo(phhihB*CJPJphh9-|B*CJPJphh9-|h9-|B*CJPJphhih?2B*CJPJph hih(>6B*CJPJph hihP|B*CJPJo(phhihP|B*CJPJphhih(>B*CJPJphhih/NB*CJPJph hih/NB*CJPJo(ph hih(>B*CJPJo(ph ,.<B $$G$Ifa$gdi dhG$H$gd WD`gd WD`gdgdNS WD`gd 'gd=b] WD`gdMgd?6 bWD`bgd(> bWD`bgd*` d =EV^ ƷƷƷgWh TB* CJOJPJQJph.h8hUtPhUtPB* CJOJPJQJo(phhm9 hCJOJPJQJo(h`ICJOJPJQJo(huB*CJPJphhih)WB*CJPJphhih(>B*CJPJphhihB*CJPJphhB*CJPJphhhB*CJPJphhih9-|B*CJPJphLNx|$06H`hj*qdTdTdTdTdh1h 'CJOJPJQJo(h 'CJOJPJQJo(#h=b]B*CJOJPJQJ_H ph,h\h=b]B*CJOJPJQJ_H o(ph&h=b]B*CJOJPJQJ_H o(phhMCJPJo(hMCJPJh '@ CJOJPJQJo(h'@ CJOJPJQJo(h(%h 'CJOJPJQJo(#h(%h '@ CJOJPJQJo(*,.026:<@FRTz(*BFT˹yiyiyiyiyiy\yiy\L\Ch'CJPJo(h'h'CJOJPJQJo(h'CJOJPJQJo(h 2hCJOJPJQJo(hCJOJPJQJo(h T5CJOJPJQJo("h8hk45CJOJPJQJo("h8h.5CJOJPJQJo("h8h>35CJOJPJQJo("h8h"h8h5CJOJPJQJo(hsCJOJPJQJo(h\hCJOJPJQJo(hCJOJPJQJo(hQ95CJOJPJQJo("h8hO>l5CJOJPJQJo("h8hQ95CJOJPJQJo("h8h@XZ\z촥||m_m|m|m|_m|m|m|m|hCJOJPJQJaJhCJOJPJQJaJo(#h*VHhCJOJPJQJaJo(,h*VHhB*CJOJPJQJaJo(phh ShB*QJaJph)h*VHhB*CJOJPJQJaJph#h*VHhCJOJPJQJ\aJ h*VHhCJOJPJQJaJ&h*VHhCJOJPJQJ\aJo(%xzkd$$Ifl4\/ "S  t(0644 l` alf4p(ytz~>\d$G$H$Ifgd$d$G$Ifa$gd d$G$Ifgd $$G$Ifa$gdi 8:z|6<|~ƴƢkk\hCJOJPJQJaJo(&h*VHhCJOJPJQJ\aJo( h*VHhCJOJPJQJaJ#hhCJOJPJQJaJo(#h*VHhCJOJPJQJaJo(#h3|hCJOJPJQJaJo(,h*VHhB*CJOJPJQJaJo(phh ShB*aJph)h*VHhB*CJOJPJQJaJph$kdF$$Ifl4O\/ "S  t(0644 l` alf4gX:Gp(yt:zd$G$H$Ifgd$d$G$Ifa$gd d$G$Ifgd d$Ifgd $$G$Ifa$gdiz|kdw$$Ifl43\/ "S  t(0644 l` alf4gX:Gp(yt|8|$d$G$Ifa$gd d$G$Ifgdd$G$H$Ifgd $$G$Ifa$gdi |~kd$$Ifl4#\/ "S  t(0644 l` alf4gX:Gp(yt~Nvd$G$H$Ifgd$d$G$Ifa$gd d$G$Ifgd d$Ifgd $$G$Ifa$gdi "vx|Z&Z*Z,Z0Z>ZBZDZFZHZJZlZrZZZZZZZZZZZ[[[4[6[йݹݩݚйݹttt#h*VHhCJOJPJQJ\aJ&h*VHhCJOJPJQJ\aJo(hCJOJPJQJaJo(hCJOJPJQJaJU,h*VHhB*CJOJPJQJaJo(phh ShB*aJph#h*VHhCJOJPJQJaJo( h*VHhCJOJPJQJaJ-vxkd$$Ifl4\/ "S  t(0644 l` alf4gX:Gp(ytx|(ZFZnZZd$G$H$Ifgd$d$G$Ifa$gd d$G$Ifgd & F d$If^`gd $$G$Ifa$gdi ccndsvaINS[oir\O(uvq_T0 4.cc_si_SaIN0 5.q`ƀAlclǏ zSƀAlclvyrp0 6.NoirclvvQN_07,{Nz0oirRRf[i 21.ccoRf[v[INTxvzQ[0 2.cc[!jW0md^8^pe0JSpg0h‰R^[y0ndsI{vi_0 3.NoRf[vSU\{Q0 4.NutoRf[!jWToRf[oHef[_!jWvi_08,{kQz0US[!jW 31.ccUS[Y l\0Y nl0@{Y~ooRf[Spev+TINS)R(u@oSm^penc{Spevel0 2.q`Y l\~oT )R(u?\openc{oRf[Spevel0 3.q`Wagner-NelsonlBl8T6e^8^pe0 4.N@oSm^N?\oSm^vvNsQ|09,{]Nz0Y[!jW 31.ccN[!jWY l\~oT @oSm^~eSSlQ_0oRf[Spev+TINT{el0 2.cc[!jWv$R+Rel0 3.q`N[!jW@{Y~o@oSm^~eSSlQ_ToRf[Spev{lQ_0 4.N㉌N[!jWY nlT N[!jWY l\~o@oSm^~eSSlQ_ToRf[Spev{lQ_010,{ASz0YBRϑ~o 21.ccYBRϑQpe0s^GW3z`@oSm^TNUSBRϑ~o@oSm^ ee z_lS:N͑ Y~oTe z_vel0 2.ccUS[!jWYBRϑ~oTySpev[INT{el0 3.q`S[!jWYBRϑ~ov gsQSpev[IN11,{ASNz ^~'`oirRRf[11.cc^~'`oirRRf[v[IN yrpNƋ+Rel0 2 ccs|l^~'`oirRRf[vRRf[e zTyr_0 3.q`s|l^~'`oirRRf[BlSpevel0 3.q`^~'`oirRRf[N~'`oirRRf[vnds uirJSpgI{Spev N Tp012,{ASNz ~wSt(WoirRRf[-Nv^(u0.51cc~wi_0 2q`AUC,AUMCv{lQ_013,{AS Nz oirRRf[(W4N^of[-Nv^(u0.51.cc4N^~oeHhv;Nel0 2.ccRQ`vBRϑel0 3.ccluoirvKmv4N^^(u0 4.q`~oeHh*NSOSTluoirvKmv;NQ[0 5.NyrkNv~oeHh014,{ASVz oirRRf[(Weoxvz-Nv^(u21.cceooirRRf[xvzvW,gQ[NW,gel0 2.ccuir)R(u^TuirI{He'`ċNvi_NՋel0 3.cccʑ6RBRvSOQYċNelSBRϑel0 4.q`eooirRRf[xvzv\O(u0 5.Nuir7hThKmvyrpTel015,{ASNz oirRRf[xvzۏU\21.ccutoirRRf[!jWv[INNyrp0 2.ccPK-PD!jWv[INNyrp0 3.q`SOoirRRf[v[INNyrp0 4.q`Kb'`oirRRf[v[INTyrp0 5.NeoirRRf[v[INSq_TV }0 N0SYePgN;NSfN heCg;N 0uiroBRf[ToirRRf[ 0 hQVؚI{;SoYePg^xvzOĉRYePg NlkSuQHr>y 2003t^ ,{NHr0 ]y_;N 0oBRf[ 0 nfؚI{Ye ASN V[~ĉRYePg NlkSuQHr>y 2003t^ ,{NHr0 ]y_;N XokS NoR;N 0oBRf[ 0 YebT21N~ zYePg -NV;SoybQHr>y 2002 t^ ,{VHr0 kk2m;N 0oBRf[ 0  ]NN V[~͑pYePg 2000t^5g ,{VHr0 1gvq\ 0oireBRW 0 Sf[]NQHr>y 2003t^8g ,{NHr0 Fl_;N 0oireBRWNeb/g 0 NlkSuQHr>y 1998t^12g ,{NHr0 sQq\ Qlf[;N 0uSoirxvz 0 NlkSuQHr>y 1997t^12g ,{NHr0 Malcolm Rowland Thomas N. Tozer;N HNu Ğt;Nы 04N^oNRRf[NoHeRRf[ 0 NlkSuQHr>y 2012t^9g ,{NHr0 s^vQ;N 0-NobRvÀlЏNBRW 0 Sf[]NQHr>y 2010t^7g ,{NHr0 hgQ;N 0|~oNRRf[ 0 ёf[QHr>y 2017t^2g ,{NHr0 mQ0b~ċ[ N 8he_ A A.wSՋ B._wSՋ C.e D.g E.vQN N b~~TċRSO| b~~TċRSO|kO%1.XQRShs202.s^eKmb~203.g+gՋb~60;`100 N0f[/gڋO f[`Nbg N GP YՋ\O _0vSNNf[`Nbg0NNbJT(uN N Tv zI{ GW^\ GPL:N0NNv`l0lTaY NlfQY cv(uY0,g zY gSs N NoL:N \ cf[!h gsQĉ[Sm,g zvf[`Nb~0 kQ0'Y~[8h Yef[b bf[/gYXTO~{z     PAGE  PAGE - 6 - ZZkd $$Ifl4*\/ "S  t(0644 l` alf4gX:Gp(ytZZZZZZ[6[l[$d$G$Ifa$gd d$G$Ifgdd$G$H$Ifgd $$G$Ifa$gdi6[:[j[l[n[r[z[[[[[[["\$\F\X\Z\\\\\\\\\\\\]]X]^]]]]]]]]]]]<^Ǻّـّǀǀǀn٣#h?hCJOJPJQJaJo( h*VHhCJOJPJQJaJ#hB*CJOJPJQJaJph,h*VHhB*CJOJPJQJaJo(phh ShB*aJph#h*VHhCJOJPJQJaJo(&h*VHhCJOJPJQJ\aJo(#h*VHhCJOJPJQJ\aJ+l[n[kd; $$Ifl4\/ "S  t(0644 l` alf4gX:Gp(ytn[r[[[[[$\Z\\$d$G$Ifa$gdd$G$H$Ifgd d$Ifgd $$G$Ifa$gdi\\kdl $$Ifl4\/ "S  t(0644 l` alf4gX:Gp(yt\\\\\\]Z]]$d$G$Ifa$gdd$G$H$Ifgd d$Ifgd $$G$Ifa$gdi]]kd $$Ifl4\/ "S  t(0644 l` alf4gX:Gp(yt]]]]]>^t^^$d$G$Ifa$gdd$G$H$Ifgd d$Ifgd $$G$Ifa$gdi<^B^N^T^r^x^^^^^^^^^^^^^^^^^*_,_._0_4_8_>_B_H_J_V_Z_\_z_____ݼ݄rdddhCJOJPJQJaJ#hB*CJOJPJQJaJph&h*VHhCJOJPJQJ\aJo(,h*VHhB*CJOJPJQJaJo(phh ShB*aJph#h*VHhCJOJPJQJ\aJhCJOJPJQJaJo(#h*VHhCJOJPJQJaJo( h*VHhCJOJPJQJaJ'^^kd$$Ifl4 \/ "S  t(0644 l` alf4gX:Gp(yt^^^^^,_X__$d$G$Ifa$gdd$G$H$Ifgd $$G$Ifa$gdi__________` `&`N`T`V`z`|`````````aa"a*a,aɲɏ}}}}}n}`n}`n}}nhCJOJPJQJaJhCJOJPJQJaJo(#h*VHhCJOJPJQJaJo( h*VHhCJOJPJQJaJ#hB*CJOJPJQJaJph,hS?hB*CJOJPJQJaJo(ph,h*VHhB*CJOJPJQJaJo(phh ShB*aJph#h*VHhCJOJPJQJ\aJ__kd$$Ifl4\/ "S  t(0644 l` alf4gX:Gp(yt_____`d$G$H$Ifgd$d$G$Ifa$gd d$Ifgd $$G$Ifa$gdi` `kd0$$Ifl4\/ "S  t(0644 l` alf4gX:Gp(yt `&`N`V`|````ad$G$H$Ifgd$d$G$Ifa$gd d$Ifgd $$G$Ifa$gdiaakda$$Ifl4W\/ "S  t(0644 l` alf4gX:Gp(yta"aJaNaaaab2bd$G$H$Ifgd$d$G$Ifa$gd d$Ifgd $$G$Ifa$gdi,aHaJaNaRa~aaaa bb2b4b8b:bXbZb\bbbbbbbbbbb c"c$c&c(cij۳۳۳ۦăuuuuucSh8h5CJOJPJo("hh=b]5CJOJPJQJo(hCJOJPJQJaJhCJOJPJQJaJo(&hB*CJOJPJQJaJo(phh ShB*aJph h*VHhCJOJPJQJaJ,h*VHhB*CJOJPJQJaJo(ph#h*VHhCJOJPJQJaJo(#hrehCJOJPJQJaJo( 2b4bkd$$Ifl4t\/ "S  t(0644 l` alf4gX:Gp(yt4b:bXb\bbbbb"cd$G$H$Ifgd$d$G$Ifa$gd d$Ifgd $$G$Ifa$gdi"c$c&cgdNSkd$$Ifl4\/ "S  t(0644 l` alf4gX:Gp(yt(c*c>c@cLccccccccccdd d,d.d8d:dTdVdhdjdvdddd e@eZejepeeeeeeeeLfNfffffffññññââââââñññññzzzzzzhsCJOJPJQJhsCJOJPJQJo(h=OihsCJOJPJQJh*VHhsCJOJPJQJ#h*VHhs@ CJOJPJQJo(h*VHhsCJOJPJQJo(hp5CJOJPJo(h8hm9 5CJOJPJo(h8hp5CJOJPJo(0&c@ccddde\eeNfffffRgnggg $$Ifa$gdi WD`gdsgdNS & F edpG$H$^e`gds$a$gdNSffffffg gggggg$g*g2g8g*CJOJPJQJo(hs>*CJOJPJQJo(h hsCJOJPJQJo(hsCJOJPJQJo(h]S5CJOJPJQJo("h8hPc5CJOJPJQJo("h8h^5CJOJPJQJo(&h8hm9 5CJOJPJQJaJo(hsh=b]5CJOJPJo(ggggzqe $$Ifa$gdi $Ifgdikd$$Ifl:0U"7 t0644 lagAytigggggggggggggggggggggggghhhhhƴgQ+h8hCJKHOJPJQJ^JaJo(<hhCJKHOJPJQJ^JaJfHo(q <hhCJKHOJPJQJ^JaJfHo(q h:|5CJOJPJQJo("hh5CJOJPJQJo(hm9 5CJOJPJQJo(hs5CJOJPJQJhsCJOJPJQJo(hLDhsCJOJPJQJo(ggggzqe $$Ifa$gdi $Ifgdikd$$Ifl:0U"7 t0644 lagAytiggggzqe $$Ifa$gdi $Ifgdikd $$Ifl:0U"7 t0644 lagAytiggggznn $$Ifa$gdikd$$Ifl:0U"7 t0644 lagAytiggggh0i2i6i8iizuuj_ZXXXXgdC WD`gdC WD`gdgdUtPkdL$$Ifl:0U"7 t0644 lagAyti hhhii.i0i2i4i8i:i>i@iDiFiJiLiXiZi\i`ibinipizi|i~iiiiԽzjzYzj!h'0JCJOJaJmHnHuh Fhlr0JCJOJaJo((jh Fhlr0JCJOJUaJo(hlr hlr0Jjhlr0JUhN'jhN'Uh5 h /CJOJPJo(-hm9 5B*KHOJPJQJ^JaJo(phDDDh hWCJOJPJQJo(hUtPCJOJPJQJo(h5CJOJPJQJo(>iBiDiHiJi\i^i`i~iiiiigdC$&#$a$gd2y hh]h`hgdF &`#$gd F C09&P 0p1C2P:p. A!4"#$% $$Ifl!vh#v#v*#v#v:V l0!,,55*55/ alyt/N$$Ifl!vh#v#v*#v#v:V l0!,,55*55/ alyt/N$$Ifl!vh#v#v*#v#v:V l0!,,55*55/ alyt/N$$Ifl!vh#v#v*#v#v:V l0!,,55*55/ alyt/N%$$Ifl!vh#v#v#vS#v:V l4p  t(06,555S5` alf4p(yt%$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4p(yt/$$Ifl!vh#v#v#vS#v:V l4O  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l43  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4#  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4*  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4   t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4W  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4t  t(06,555S5` alf4gX:Gp(yt/$$Ifl!vh#v#v#vS#v:V l4  t(06,555S5` alf4gX:Gp(yt$$If!vh#v7#v:V l: t06575gAyti$$If!vh#v7#v:V l: t06575gAyti$$If!vh#v7#v:V l: t06575gAyti$$If!vh#v7#v:V l: t06575gAyti$$If!vh#v7#v:V l: t06575gAytii[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[Ci[C#s002 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@PJ_HmH nHsH tHN`N hcke $1$a$$CJ KHPJ_HaJmH nHsH tHRR wh 1$$dBTJ@&5CJ,KH,PJ\aJ,ff wh 2$$7$8$@&H$^`a$ KHOJPJQJ^JaJ mHsH$A`$ ؞k=W[SOBi@B nfh&Ŝ]6ҨN=Ina7qb&>!"h [+Lxz)WVOg%Ţ|8Mă#/8'=QU*C`CW{D6/[YL%+n+{\osM/~iBcAX/=x E'5&\h4da,yE\})laR^*zyV-WoWZN]:mV=tCWrb*IVURU|nc`|*^PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!ftheme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] > (((+p < ` *T6[<^_,a(cfghi #*7>AHLNPU xzz||~vxZZl[n[\\]]^^__` `aa2b4b"c&cggggg>ii!"$%&'()+,5689:;<=?@BCDEFGIJKMOQRSTV $+! !@ @H 0(  0(  B S  ? FJ^bfhostv ow|   " 5 8 E I L Y [ m o   & ) F J N Y h k y |   0 3 D H L R j m x {    0 4 8 B n q   ' * U Z ^ i o )8SWmox{ $:=UXor !MSgijo~ "(HIKQabq  !#')2:BIPT]ahjqr   <?mn} Z[rsbe-0x| <?ss333ss3333 mognG I U W H W F P 2 @ W g PShl   "2pqx <?01wx~  FefG G H H F F N 2 2 W PP    q <? B_~(= ADzKP z2j 8=Rt/t6XTH!D"Tv:dz>{2>luz)e8LtP  VE -r : & + m9 @ P 8 ^ rt 8  c * 6 !P -'@F0b Z sR3Qm5RnC^MR5qP,"b5Nl` L e%Riu<`cc{ (]f`>M&+A.Nor^%8NNzL^$,q@NAi\ph#j~Z$%5dI : T ~m 9!%!"Lj#V$EC$ I$j'%f_%$&L&&' '('$<'N'1(8(X(+)m)v**Q*v*+A++q+ .J.1N.g.bt.V// /#/b/X0mD0^0Lp0t0n1.1P1R1W1w1!2U2DX2>3l3v34$4Q4]445 555mN5 6?6A6H6"f6(j67\ 7P7F]7{88 88n-9Q9}91:C:N;)g;&<1r<Lx<G>E?r? @,@T6@$E@AZ@h@Sm@ A AB A,A,A8ANAbABFBOBU`BwB=4CZC|fCuCLDh]D}DE:EaEJcE F$F-FGFRUFaF2GGHoH; I'IhqBhLh6[h^i io#i9iciNpij1jTkYk]k<lcl@mNQmnenWnHJoQop$p]pvpwq~qCr r[r|r s#+s _s2tt{7tHt^tSufu|uvp$v[JvwvBwVYwvlwnww2x x/x2Ix2yG$yCyTzgz@z.[zIz {k!{$"|W%|'|9-|e|! } }e}g}~^~m~ ,@ uv~-N{UZfA~-0i|(q0/KS3a15KSS4' ]ky<%PPa: Ak UP||G %'08]B7Y!l?2 i:r&m W&.ISTMcz5 .B[*v@EE8NEmJFAOyuMC l,]c~LNZ_ #6'~pYZQaT'}TX5gilrOw{ ;/)S^N"#>sRUtKO^bFfW QXb V\Q s : RM ch'$Zg=5A!ZbkWz&$4LH\Ijv UTfa8\N.RI[;pp!PelDOZ^]s J9K#<9kn'W)/;TYx Dg)3FJdQ/$S1c+h AGNSK]q5mon!`JjhC`UBHMKR~MWqk!5Z<?Ju`x(.A=Zy1'-frs|N! 'l>}O7<>PWucUi5])(>`I k%CF1X9 r8oy AMg/?7fx VxM?O{^ *;E=XsGIJ>Ndwx}{//8KTNiu]+-@djnc NRps + k4j?nGn D8M)WR'<Z(WmsUoI1A_{#$9Vzq @ZUnknownuser Administrator G.[x Times New Roman5Symbol3. .[x Arial;= |8ўSOSimHei;([SOSimSun5. .[`)TahomaA5 N[_GB2312N[?= .Cx Courier New7. [ @Verdana;WingdingsA$BCambria Math 1hY G GY< "< "!-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[4d=   2qHP ?JcE2! xx* JC:\Documents and Settings\new\Application Data\Microsoft\Templates\s^Le.dot-NVwm m'Yf[,gyu z'Y~2020Hr _o(u7bYang%AM00w~ +?>"2B Rbr: i Z'`IZ'8         Oh+'0 $ D P \ ht|(йѧγ̴٣2020棩 ΢û ƽ.dotYang6Microsoft Office Word@Vn @1Ax@>@ < ՜.+,0 X`t|  ΢й"     !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWYZ[\]^_`abcdfghijklmnopqrstuvwxyz{|}~Root Entry F`IK @Data X1Tablee-_WordDocument ESummaryInformation(DocumentSummaryInformation8MsoDataStore@2 0C DEW3FTA==2@2 0C Item  PropertiesUCompObj n   FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q