李德海

李德海

博士

教授

博士生导师

科 室：

海洋天然药物化学

办公电话：

0532-82031619

电子邮箱：

dehaili@ouc.edu.cn

联系地址：

山东省青岛市鱼山路5号中国海洋大学医药学院海洋馆107 266003

研究方向：

主要从事海洋天然药物化学研究。主要包括：

1. 深远海、海洋动植物共附生等微生物的分离及功能基因挖掘利用；

2.海洋微生物药物先导化合物的发现、结构优化及构效关系研究；

3.海洋来源真菌次级代谢产物的生物合成。

个人简介

李德海，男，博士，教授，博导，医药学院副院长。国际期刊Curr. Org. Chem、The Natural Products Journal、Lett. Org. Chem.编辑；应用海洋学学报（中文核心期刊）第六届编委会委员。主要从事海洋天然药物化学研究，致力于利用化学和生物学手段从海洋微生物中发现具有潜在药用价值的活性成分。近年来Curr. Opin. Biotech.、J. Med. Chem.、Org. Lett.、J. Org. Chem.、J. Nat. Prod. 等发表SCI收录论文130余篇（第一或通讯作者80余篇），个人H指数36，i10指数97（GoogleScholar数据）；已授权专利9项。主持承担国家自然科学基金、山东省、教育部等二十余个项目。

教育背景

2002.09~2007.06

中国海洋大学

药物化学

博士

1998.09~2002.06

山东大学

药学

学士

工作经历

2014.08~2015.08

Universityof California, Los Angeles

(Yi Tang group)

访问学者

2014.01~至今

中国海洋大学 医药学院

教授

2009.10~2013.12

中国海洋大学 医药学院

副教授

2007.07~2009.07

University of British Columbia, (Raymond Andersen group)

博士后

学术兼职

中国药学会高级会员，中国药学会海洋药物专业委员会委员、青年委员会主任；中国海洋湖沼学会药学分会副秘书长。

荣誉奖励

教育部“新世纪优秀人才支持计划”（2012年）、“山东省自然科学杰出青年基金”（2014年）获得者，入选青岛海洋科学与技术国家实验室“鳌山人才”优秀青年学者（2015年）、山东省“泰山学者青年专家”（2018年）、教育部“长江学者”青年专家（2019年）、自然资源部“高层次科技创新人才”（第三梯队）（2019年）。被评为获第九届青岛市青年科技奖（2013年）、国家海洋局优秀科技青年（2015年）、美国化学会会员奖（ACS Membership Award）（2015年）、山东省自然科学学术创新奖（2016年）、中国药学会以岭生物医药奖（2018年）。

承担课程

药物化学（本科生课程）

大学生职业规划（本科生课程）

天然有机化合物结构解析（研究生课程）

海洋天然药物化学（Marine Natural Products Chemistry，研究生英文课程）

研究进展

以海洋微生物活性代谢产物发现为核心，利用多学科高度交叉的前沿技术探索海洋微生物的功能基因、活性分子及其潜在的药用价值。(1)开拓了深海药用微生物新资源、挖掘了菌株沉默基因资源，提高了海洋生物资源的利用效率：深海微生物研究少、潜力大，是亟待开发的药用新资源。发挥依托单位在海洋学科的优势，获得了200余份千米以下深海样品；针对深海微生物培养难的问题不断探索，获得了1500余株真菌和放线菌，报道了80余个新结构。并针对海洋微生物大多数活性分子的编码基因处于沉默状态的问题，融合“OSMAC策略”、“表观遗传修饰”、“基因组采掘”等新技术形成了“基因-化学-活性”相结合的海洋微生物挖掘利用研究模式，激活产生了近百个新型活性代谢产物。（2）阐明了多个海洋复杂分子的精确结构和潜在药用价值：针对天然产物结构确定难度大的挑战，利用量子化学计算等新技术，精确鉴定了300余个结构新颖的化合物（包括20余种新骨架），其中100余个具有抗肿瘤等生物活性。鉴于新颖的结构和显著的生物活性，近年来所发现的Penicitol A等11个分子被权威评论性期刊Nat. Prod. Rep.评为“热点化合物” (Hot off the press)。

代表性成果

近五年代表性论文

（*通讯作者；#共同第一作者）

1.       Guangwei Wu#, Guihong Yu#, Yunjia Yu#, Shuang Yang#, Zhongwei Duan, Wei Wang*, Yankai Liu, Rilei Yu, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Chemoreactive-inspired discovery of influenza A virus dual inhibitor to block hemagglutinin-mediated adsorption and membrane fusion. J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c00312

2.       Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang* and Dehai Li*. Overexpression of Global Regulator brlaeA Leads to the Discovery of ew Polyketide in Fungus Penicillium rocae HDN-12-143. 2020,Front. Chem. DIO: 89/fchem.2020.00270.

3.       Lu Wang, Jieying Jiao, Dan Liu, Xiaomin Zhang, Jing Li, Qian Che, Tianjiao Zhu, Dehai Li* and Guojian Zhang*. Cytotoxic Meroterpenoids from the Sponge‐Associated Fungus Alternaria sp. JJY‐32. Chem. Biodiv. 2020, DIO: doi.org/10.3389/fchem.2020.00270

4.       Junxiao Wang, Chunxiao Sun, Mudassir Shah, Guoxian Zhang, Qianxun Gu, Tianjiao Zhu, Qian Che*, Dehai Li*. New Metabolites from a Mariana Trench-Derived Actinomycete Nocardiopsis sp. HDN17-237. J. Asian Nat. Prod. Res.,  doi.org/10.1080/10286020.2019.1681411

5.       Chunxiao Sun, Shah Mudassir, Zhenzhen Zhang, Yanyan Feng, Yimin Chang, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang*, Dehai Li*. Secondary Metabolites from Deep-sea Derived Microorganisms. Curr. Med. Chem. 2020, DOI : 10.2174/0929867326666190618153950

6.       Changjun Lu, Changlong li, Qi Gan, Yi Zhao, Congcong Liu, Qianqun Gu, Tianjiao Zhu, Guojian Zhang, Qian Che and Dehai Li*. Phomanones A-C from Phoma sp. HDN16-618, a Mariana Trench Fungus. Nat. Prod. Commun. 2020,https://doi.org/10.1177/1934578X19858813.

7.       Meilin Zhu, Xuewen Zhang, Xuenan Huang, Haotian Wang, Komal Anjum, Qianqun Gu, Tianjiao Zhu, Guojian Zhang, Dehai Li*. Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures and Biological Activities. J. Nat. Prod. 2020, 83, 6, 2045–2053

8.       Qiuying Wang, Kaijin Zhang, Wei Wang, Guojian Zhang, Tianjiao Zhu, Qian Che, Qianqun Gu, Dehai Li*. Amphiepicoccins A−J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus Epicoccum nigrum HDN17-88.J. Nat. Prod.2020, 83, 2, 524–531

9.       Guoliang Zhou, Xiaohui Chen, Xiaomin Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li* .PrenylatedpTerphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ5. J. Nat. Prod. 2020, 83, 1, 8–13

10.   Mudassir Shah#, Chunxiao Sun#, Zichao Sun, Guojian Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu*, Dehai Li*. Antibacterial Polyketides from Antarctica Sponge-derived Fungus Penicillium sp. HDN151272. Mar. Drugs 2020, 18, 71-79;

11.   Ling Peng#, Liangwei Li#, Xiaochuan Liu, Jianwei Chen, Chengcheng Shi, Wenjie Guo, Qiwu Xu, Guangyi Fan, Xin Liu*, Dehai Li*. Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabileHXQ-H-1.J. Fungi2020, 6, 7-18; doi:10.3390/jof6010007

12.   Congcong Liu, Zhenzhen Zhang, Yanyan Feng, Qianqun Gu, Dehai Li, Tianjiao Zhu*,. Secondary Metabolites of an Antarctic Derived Fungus Penicillium crustosumHDN153086. Nat Prod Res. 2019, 33(3), 414-419.

13.   Guihong Yu, Zichao Sun, Jixing Peng, Meilin Zhu, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and aXylariasp. J. Nat. Prod., 2019, 82, 7, 2013-2017

14.   Jing Yu, Huan Han, Xianyan Zhang, Chuanteng Ma, Chunxiao Sun, Qian Che, Qianqun Gu, Tianjiao Zhu, Guojian Zhang,Dehai Li*. Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyisYJ-11. Mar. Drugs2019, 17, 446-457.

15.   Tingting Zhao, Yimin Chang, Tianjiao Zhu, Jing Li, Qianqun Gu, Dehai Li, Qian Che* and Guojian Zhang*.α-Pyrone derivatives with cyto-protective activity from two TaklaMakan desert soil derived actinomycete Nocardiopsis strains recovered in seawater based medium.Nat. Prod. Res. 2019, 33 (17), 2498–2506

16.   Xueping Ge, Chunxiao Sun, Yanyan Feng, Lingzhi Wang, Jixing Peng, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li, Guojian Zhang *. Anthraquinone Derivatives from a Marine-derived Fungus SporendonemacaseiHDN16-802. Mar. Drugs2019, 17, 334-344.

17.   Chunxiao Sun, Xueping Ge, Shah Mudassir, Guihong Yu, Qian Che, Guojian Zhang, Jixing Peng, Tianjiao Zhu*, Dehai Li*. New Glutamine-Containing Azaphilone Alkaloids from Deep-sea Derived Fungus Chaetomium globosum HDN151398. Mar. Drugs, 2019, 17, 253-263.

18.   Liang Qiao, Zhongwei Duan, Yinghan Chen, Yepeng Luan, Qianqun Gu, Yan-Kai Liu*, and Dehai Li*. Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues. J. Org. Chem. 2019, 84, 4451-4457

19.   Guihong Yu, Qiuying Wang, Shan Liu, Xiaomin Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Methylsulfonylated Polyketides Produced by Neosartoryaudagawae HDN13-313 via Exogenous Addition of Small Molecules. J. Nat. Prod., 2019, 82, 998−1001

20.   Guoliang Zhou, Liang Qiao, Xiaomin Zhang, Chunxiao Sun, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Fusaricates H-K and Fusolanones A-B from a Mangrove Endophytic Fungus Fusarium solaniHDN15-410. Phytochemistry 2019, 158, 13-19

21.   Tingting Yao, Jing Liu, Zengzhi Liu, Tong Li, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li,Qianqun Gu, Wenli Li*. Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery. Nature Comm. 2018 9, 4091.

22.   Yinghan Chen, Dehai Li*, and Yankai Liu*. Diversified Synthesis of Chiral Chromane-Containing Polyheterocyclic Compounds via Asymmetric Organocatalytic Cascade Reactions. ACS Omega 2018, 3, 16615−16625.

23.   Guihong Yu, Guangwei Wu, Zichao Sun, Xiaomin Zhang, Qian Che, Qianqun Gu, Tianjiao Zhu, Dehai Li, Guojian Zhang*. Versixanthones N-P, Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-associated Fungus Aspergillus versicolor HDN1009. Mar. Drugs2018, 16,335-242; doi:10.3390/md16090335

24.   Qian Che,#LiangQiao,# Xiaoning Han, Yankai Liu, Wei Wang, Qianqun Gu, Tianjiao Zhu, Dehai Li*. Anthranosides A-C, Anthranilate Derivatives from a Sponge-Derived Streptomyces sp. CMN-62. Org. Lett. 2018, 20, 5466−5469.

25.   Zhenzhen Zhang, Xueqian He, Qian Che, Guojian Zhang*, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Sorbicillasins A–B and Scirpyrone K from a Deep-Sea-Derived Fungus, Phialocephala sp. FL30r. Mar. Drugs2018, 16,245-254; doi:10.3390/md16070245

26.   Zhenzhen Zhang, Xueqian He, Guangwei Wu, Congcong Liu, Changjun Lu, Qianqun Gu, Qian Che, Tianjiao Zhu, GuojianZhang,* and Dehai Li*. Aniline-tetramic Acids from the Deep-sea Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. J. Nat. Prod. 2018, 81 (7), 1651–1657

27.   Liang Qiao, Zhongwei Duan, Xiaona Wu, Dehai Li*, Qianqun Gu, and Yankai Liu*. Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles. Org. Lett. 2018, 20 (6), 1630–1633

28.   Wenqiang Guo#, Shuai Wang#, Na Li, Feng Li, Tianjiao Zhu, QianqunGu,  Peng Guo* and Dehai Li*. Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladiumkiliense HDN11-112. J. Nat. Prod. 2018, 81 (4), 1050–1054 (Most read articles)

29.   Guangwei Wu#, Xin Qi#, Xiaomei Mo, Guihong Yu, Qiang Wang, Tianjiao Zhu, Qianqun Gu, Ming Liu*, Jing Li, and Dehai Li*. Structure-based Discovery of Cytotoxic Dimeric Tetrahydroxanthones as Potential Topoisomerase I Inhibitors from a Marine-derived Fungus. Eur. J. Med. Chem. 2018, 148, 268–278

30.   Feng Li, Zhenzhen Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu andDehai Li*. Determination of Taichunamide H and Structural Revision of Taichunamide A. Org. Lett. 2018, 20 (4), 1138–1141.

31.   Guihong Yu, Yanjuan Wang, RileiYu,  Yanyan Feng, Lu Wang, Qian Che, Qianqun Gu,  Dehai Li, Jing Li and Tianjiao Zhu*. Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmusluteoalbus HDN13-530.RSC Adv. 2018, 8, 53-58.

32.   Xueqian He#, Zhenzhen Zhang#, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li *. Varilactones and Wortmannilactones Produced by Penicillium variabile Cultured with Histone Deacetylase Inhibitor. Arch. Pharm. Res. 2018, 41, 57-63

33.   Feng Li#, Wenqiang Guo#, Li Wu, Tianjiao Zhu, Qianqun Gu, Dehai Li, Qian Che*. Saroclazines A-C, thio-diketopiperazines from mangrove-derived fungi SarocladiumkilienseHDN11-84. Arch. Pharm. Res. 2018, 41, 30-34

34.   Guihong Yu#, Shuai Wang#, Lu Wang, Qian Che, Tianjiao Zhu, Guojian Zhang, Qianqun Gu, Peng Guo*, and Dehai Li*. Lipid-Lowering Polyketides from the Fungus Penicillium SteckiiHDN13-279. Mar. Drugs2018, 16, 25-37; doi:10.3390/md16010025

35.   Zhenzhen Zhang, Xueqian He, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile. J. Nat. Prod. 2017,80 (12), 3167–3171

36.   Zhen Yang#, Meilin Zhu#, Dehai Li*, Rong Zeng*, Bingnan Han*. N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway. Bioorg. Med. Chem. 2017, 25(24),6614-6622

37.   Fengli Yuan, Liang Qiao, Yinghan Chen, Xin Qi, Yankai Liu, Dehai Li, Qianqun Gu, Jing Li*, Ming Liu *. AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells. Mar. Drugs2017, 15, 346; doi:10.3390/md15110346.

38.   Meilin Zhu, Zhen Yang, Huimin Feng, Qi Gan, Qian Che, Tianjiao Zhu, Qianqun Gu, Bingnan Han* and Dehai Li*. Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellumHDN13-309. RSC Adv., 2017, 7, 48019 – 48024.

39.   Man-Cheng Tang#, Xiaoqing Cui#, Xueqian He, Zhuang Ding, Tianjiao Zhu, Yi Tang*, Dehai Li*. Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products. Org. Lett. 2017, 19 (19), 5376–5379

40.   Xiaoning Han, Zengzhi Liu, Zhenzhen Zhang, Xiaomin Zhang, Tianjiao Zhu, Qianqun Gu, Wenli Li, Qian Che*, and Dehai Li*. Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF. J. Nat. Prod. 2017, 80 (5), 1684–1687

41.   Weiyi Zhang#, Qian Che#, Hongsheng Tan, Xin Qi, Jing Li, Dehai Li,Qianqun Gu, Tianjiao Zhu*, Ming Liu*. Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system. Scientific Reports 2017, 7, 42180

42.   Meilin Zhu, Xiaomin Zhang, Huimin Feng, Jiajia Dai, Jing Li, Qian Che, Qianqun Gu, Tianjiao Zhu*, and Dehai Li*. Penicisulfuranols A–F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309. J. Nat. Prod.2017, 80(1), 71-75.

43.   Feng Li, Wenqiang Guo, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Versicones E-H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84. J Antibiot. 2017, 70, 174-178.

44.   Haibo Zhou, Xinhua Sun, Na Li, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Isoindolone-Containing Meroperpenoids from the Endophytic Fungus Emericellanidulans HDN12-249. Org. Lett. 2016, 18 (18), 4670–4673.

45.   Chang-Wei Li, Ming-Wen Xia, Cheng-Bin Cui*, Jixing Peng and Dehai Li. A Novel Oxaphenalenone, Penicimutalidine: Activated Production of Oxaphenalenones by the Diethyl Sulphate Mutagenesis of Marine-derived Fungus Penicillium purpurogenum G59. RSC Adv. 2016, 6, 82277–82281.

46.   Jixing Peng#, Xiaomin Zhang#, Wei Wang, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107. Mar. Drugs 2016, 14(7), 131; doi:10.3390/md14070131

47.   Meilin Zhu, Xiaomin Zhang, Huimin Feng, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Campyridones A-D, pyridone alkaloids from a mangrove endophytic fungus Campylocarpon sp. HDN13-307. Tetrahedron2016,72 (37), 5679–5683.

48.   Zhuang Ding, Liyuan Li, Qian Che, Dehai Li, Qianqun Gu, Tianjiao Zhu*. Richness and bioactivity of culturable soil fungi from the Fildes Peninsula, Antarctica. Extremophiles 2016, 20 (4), 425–435.

49.   Zhenzhen Zhang, Xueqian He, Congcong Liu, Qian Che, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Clindanones A and B and Cladosporols F and G, Polyketides from a Deep-sea Derived Fungus Cladosporium cladosporioides HDN14-342. RSC Adv. 2016, 6, 76498-76504.

50.   Haibo Zhou#, Liyuan Li#, Chongming Wu, Tibor Kurtán, Attila Mándi, Yankai Liu, Qianqun Gu, Tianjiao Zhu*, Peng Guo*, and Dehai Li*. Penipyridones A-F, Pyridone Alkaloids from Penicillium funiculosum. J. Nat. Prod. 2016, 79 (7), 1783–1790

51.   Qian Che#, Hongsheng Tan#, Xiaoning Han, Xiaomin Zhang, Qianqun Gu, TianjiaoZhu,* and Dehai Li*. Naquihexcin A, a S-Bridged Pyranonaphthoquinone Dimer Bearing an Unsaturated Hexuronic Acid Moiety from a Sponge-Derived Streptomyces sp. HDN-10-293. Org. Lett. 2016, 18 (14), 3358–3361.

52.   Ting Zhang, Meilin Zhu, Guangyu Sun, Na Li, Qianqun Gu, Dehai Li, Qian Che* and Tianjiao Zhu*. Exopisiod B and farylhydrazone C, two new alkaloids from the Antarctic-derived fungus Penicillium sp. HDN14-431. J. Asian Nat. Prod. Res. 2016, 18 (10), 959-965.

53.   Zhenzhen Zhang, Wenqiang Guo, Xueqian He, Qian Che, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Peniphenylanes A-G from a Deep-sea Derived Fungus Penicillium fellutanum HDN14-323. Planta Med. 2016, 82, 872–876. (Invited Article)

54.   Qian Che, Jing Li, Dehai Li, Qianqun Gu and Tianjiao Zhu*. Structure and Absolute Configuration of Drimentine I, an Alkaloid from Streptomyces sp. CHQ-64. J Antibiot. 2016, 69, 467–469.

55.   Guojian Zhang, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Advanced tools in marine natural drug discovery. Curr. Opin. Biotech. 2016, 42: 13-23. (Invited Review)

56.   Guihong Yu, Guoliang Zhou, Meilin Zhu, Wei Wang, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-derived Fungus Neosartoryaudagawae HDN13-313. Org. Lett. 2016, 18 (2), 244–247.

57.   Zhuang Ding, Lianqing Zhang, Juan Fu, Qian Che, Dehai Li, Qianqun Gu, Tianjiao Zhu*. Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69. J. Antibiot. 2015,68, 748-751.

58.   Xueqian He, Zhenzhen Zhang, Yinghan Chen, Qian Che, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor. J. Nat. Prod. 2015, 78 (11), 2841–2845.

59.   Xinhua Ma, Haotian Wang, Feng Li, Zhu, Qianqun Gu, and Dehai Li*. Stachybotrin G, a sulfate meroterpenoid from a sponge derived fungus Stachybotryschartarum MXH-X73. Tetrahedron Lett. 2015, 56 (50), 7053–7055.

60.   Wenqiang Guo, Zhenzhen Zhang, Tianjiao Zhu, Qianqun Gu andDehai Li*. Penicyclones A-E, Antibacterial Polyketides from the Deep-sea Derived Fungus Penicillium sp. F23-2. J. Nat. Prod.2015, 78 (11), 2699–2703.

61.   Guangwei Wu#, Guihong Yu#, Tibor Kurtán, Attila Mándi, Jixing Peng, Xiaomei Mo, Ming Liu, Hui Li, Xinhua Sun, Jing Li, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Versixanthones A–F, Cytotoxic Xanthone–Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009.J. Nat. Prod. 2015, 78 (11), 2691–2698.

62.   Meilin Zhu, Huquan Gao, Chongming Wu, Tianjiao Zhu, Qian Che, Qianqun Gu, Peng Guo* andDehai Li*. Lipid-Lowering Polyketides from a Soft Coral-Derived Fungus Cladosporium sp. TZP29. Bioorg. Med. Chem. Lett. 2015, 25 (17), 3606–3609

63.   Haibo Zhou, Liyuan Li, Wei Wang, Qian Che, Dehai Li, Qianqun Gu, and Tianjiao Zhu*. Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. J. Nat. Prod. 2015, 78 (6), 1442–1445

64.   Man-Cheng Tang, Hsiao-Ching Lin, Dehai Li, Yi Zou, Jian Li, Wei Xu, Ralph A. Cacho, Maureen E. Hillenmeyer, Neil K. Garg, Yi Tang*. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc.2015, 137 (43), 13724-13727

65.   Xuming Mao, Wei Xu, Dehai Li, Wenbing Yin, Yit-Heng Chooi, Yongquan Li, Yi Tang,* and Youcai Hu*. Epigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural products. Angew. Chem. Int. Ed. 2015, 54 (26), 7592–7596.

66.   Yi Zou, Zhajun Zhan, Dehai Li, Mancheng Tang, Ralph A Cacho, Kenji Watanabe, Yi Tang*. Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids.J. Am. Chem. Soc.2015, 137 (15), 4980–4983

67.   Shengxin Cai#, Shiwei Sun#, Jixing Peng, Xianglan Kong, Huinan Zhou, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Okaramines S-U, three new indole diketopiperazine alkaloids from Aspergillus taichungensisZHN-7-07. Tetrahedron 2015, 71 (21), 3715–3719. (Invited article)

68.   Qian Che#, Tong Li#, Xiaofang Liu, Tingting Yao, Jing Li, Qianqun Gu, Dehai Li*, Wenli Li*, and Tianjiao Zhu*.Genome Scanning Inspired Isolation of Reedsmycins A-F, Polyene-polyol Macrolides from Streptomyces sp. CHQ-64. RSC Adv. 2015,29 (5), 22777-22782.

69.   Xinhua Ma, Jixing Peng, Guangwei Wu, Tianjiao Zhu, Guoqiang Li, Qianqun Gu, and Dehai Li*.Speradines B-D, Oxygenated Cyclopiazonic Acid Alkaloids from the Sponge-Derived Fungus Aspergillus flavus MXH-X104. Tetrahedron 2015, 71 (21), 3522-3527.

70.   Wenqiang Guo, Xianglan Kong, Tianjiao Zhu, Qianqun Gu a and Dehai Li*. Penipyrols A-B and Peniamidones A-D from the Mangrove Derived Penicillium solitum GWQ-143. Arch. Pharm. Res.2015, 38, 1449–1454.

71.   Wenqiang Guo, Dan Li, Jixing Peng, Tianjiao Zhu, Qianqun Gu, and Dehai Li*. Penicitols A-C and Penixanacid A from the Mangrove Derived Penicillium chrysogenum HDN11-24. J. Nat. Prod. 2015, 78 (2), 306−310.

72.   Zhenjian Lin, Xinhua Ma, Hongjuan Wei, Dehai Li, Qianqun Gu and Tianjiao Zhu*. Spicarins A-D from Acetylated Extract of Fungus Spicaria elegans KLA03. RSC Adv. 2015, 5 (44), 35262-35266.

73.   Guihong Yu, Guangwei Wu, Tianjiao Zhu, Qianqun Gu and Dehai Li*. Cladosins F and G, two new hybrid polyketides from the deep-sea-derived Cladosporium sphaerospermum 2005-01-E3. J. Asian Nat. Prod. Res. 2015, 17 (2),120-124

专利

1.李德海，顾谦群，张国建，朱天骄。倍半萜混对二酚类化合物及其制备方法和用途，授权号： ZL201010119062.6。

2.朱天骄，顾谦群，李莉媛，李德海。一种含多硫键的哌嗪类化合物及其制备方法和用途，授权号：ZL201010119068.3。

3.顾谦群，蔡生新，李德海，朱天骄。来源于色氨酸与脯氨酸的吲哚二酮哌嗪生物碱类化合物及其制备方法和用途，授权号:ZL201110153232.7   

4.朱天骄, 车茜, 李德海, 顾谦群, 李静。一种倍半萜生物碱类化合物及其制备方法和用途，授权号：ZL 201110153202.6   

5.李德海，周会楠，朱天骄，顾谦群。细胞松弛素类化合物及其制备方法和用途，授权号：ZL 201110153240.1   

6.发明人：朱天骄，周海波，顾谦群，李德海，郭鹏。一种吡啶酮生物碱类化合物及其制备方法和用途，授权号：ZL2014061900270620

7.发明人：李德海；朱美林；顾谦群；朱天骄；李静；车茜。一类二硫桥二酮哌嗪类化合物及其制备方法和用途，授权号：ZL201510063639.3

8.发明人：李德海；朱美林；李静；顾谦群；朱天骄；车茜。一种含硫桥复杂环系生物碱类化合物及其制备方法和用途，授权号：ZL201510063692.9  

9.发明人：李德海；于桂洪；朱天骄；顾谦群；车茜；王伟。一种吲哚生物碱类化合物及其制备方法和用途，授权号：ZL20150959923.4

项目课题

1. 国家自然科学基金-山东省政府联合资助项目（U1906212），294.8万，2020.01-2023.12，主持。

2. 国家自然科学基金面上（81973234），65.6万，2020.01-2023.12，主持。

3. 山东省“泰山学者”青年专家计划（tsqn201812021），100万，2019.01-2023.12，主持。

4. 中央高校基本科研业务费专项（201941001），100万，2019.01-2021.12, 主持。