付鹏

作者:张栋时间:2019-08-26

 

博士

教授

博士生导师

科 室:

海洋天然药物化学研究室

办公电话:

0532-82031873

电子邮箱:

fupeng@ouc.edu.cn

联系地址:

山东省青岛市鱼山路5号中国海洋大学医药学院, 邮编266003

研究方向:

海洋微生物天然药物化学

个人简介

 

 

 

 

主要围绕海洋放线菌资源开展功能导向的次级代谢产物研究,从中发现具有潜在药用价值的先导化合物分子,并探索代谢产物生物合成中非酶催化的化学过程;在此基础上实现天然产物结构的化学进化,从而为深入的化学生物学研究及药物开发奠定基础。主持承担国家自然科学基金青年项目、面上项目等多项研究课题。在Nat. Commun.、Nat. Prod. Rep.、Org. Lett.、Chin. Chem. Lett.、Org. Chem. Front.、J. Nat. Prod.等本领域主流期刊上发表SCI收录论文50余篇。2021年,获校级优秀硕士学位论文指导奖。2022年和2023年连续两次被评为校优秀教师。2023年,入选山东省泰山学者青年专家。

教育背景

 

 

 

 

2008.09~2013.06

中国海洋大学

药物化学

博士(硕博连读)

2004.09~2008.06

中国海洋大学

药学

学士

工作经历

 

 

 

 

2017.08至今

中国海洋大学 医药学院

教授

 

2013.07~2017.06

美国得克萨斯大学西南医学中心

博士后

 

承担课程

 

 

 

 

天然药物化学(本科生课程)

代表性成果

代表性论文(近5年)

1.         Jingjing Shen#, Jiwen Sun#, Shupeng Yin#, Weiming Zhu*, and Peng Fu*. Structurally Diverse Macrolactams from an Antarctic Streptomyces Species. J. Nat. Prod., 2024, 87, 404−414.

2.         Shuige Zhao#, Pengcheng Yan#, Peipei Liu, Haishan Liu, Ning Li, Peng Fu*, and Weiming Zhu*. Pyridapeptides F−I, Cyclohexapeptides from Marine Sponge-derived Streptomyces sp. OUCMDZ-4539. Chin. Chem. Lett., 2024, 35,108950.

3.         Shupeng Yin#, Zhi Liu#, Jingjing Shen, Yuwei Xia, Weihong Wang, Pengyan Gui, Qian Jia, Konthorn Kachanuban, Weiming Zhu*, and Peng Fu*. Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons. Nat. Commun., 2022, 13, 5169.

4.         Yaqin Fan, Jingjing Shen, Zhi Liu, Kunyu Xia, Weiming Zhu*, and Peng Fu*. Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis. Nat. Prod. Rep., 2022, 39, 1305−1324.

5.         Shuige Zhao, Yuwei Xia, Haishan Liu, Tongxu Cui, Peng Fu*, and Weiming Zhu*. A Cyclohexapeptide and Its Rare Glycosides from Marine Sponge-Derived Streptomyces sp. OUCMDZ-4539. Org. Lett., 2022, 24,6750−6754.(封面文章)

6.         Rongxin Zhang, Xiaotang Yan, Shupeng Yin, Weihong Wang, Weiming Zhu, and Peng Fu*. Discovery of New Bohemamines and Synthesis of Methylene Methylene-Bridged Chimeric Derivatives through Natural Product Chimera Strategy. Chin. J. Chem., 2022, 40, 1413−1421.

7.         Zhi Liu, Shupeng Yin, Rongxin Zhang, Weiming Zhu, and Peng Fu*. High-Efficiency Synthesis of Carbon-Bridged Dimers via Bioinspired Green Dimerization Involving Aldehydes. ACS Sustainable Chem. Eng., 2022, 10, 655−661.

8.         Mengmeng Lan#, Tongxu Cui#, Kaichun Xia, Guodong Cui, Yiwen Chu, Peng Fu*, and Weiming Zhu*. (±)-Pyriindolin with a 2,2′-Bipyridine-spiro[furan-3,3′-indoline] Chimeric Skeleton from the Endophytic Streptomyces albolongus EA12432. Chin. Chem. Lett., 2022, 33,508−510.

9.         Rui Ma, Shan Cheng, Jiwen Sun, Weiming Zhu*, and Peng Fu*. Antibacterial Gilvocarcin-Type Aryl‑C‑Glycosides from a Soil-Derived Streptomyces Species. J. Nat. Prod., 2022, 85, 2282−2289.

10.     Kunyu Xia, Hui Luo, Rui Ma, Rongxin Zhang, Weiming Zhu*, and Peng Fu*. Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species. J. Nat. Prod., 2021, 84, 1550−1555.

11.     Jingjing Shen, Jie Wang, Hao Chen, Yi Wang, Weiming Zhu*, and Peng Fu*. Cyclamenols E and F, Two Diastereoisomeric Bicyclic Macrolactams with a Cyclopentane Moiety from an Antarctic Streptomyces species. Org. Chem. Front., 2020, 7, 310−317.

12.     Jingjing Shen#, Yaqin Fan#, Guoliang Zhu, Hao Chen, Weiming Zhu*, and Peng Fu*. Polycyclic Macrolactams Generated via Intramolecular Diels−Alder Reactions from an Antarctic Streptomyces Species. Org. Lett., 2019, 21,4816−4820.

出版著作(章节)

 

 

 

 

1.         Peng Fu. Use of Isotope Labels for NMR and MS Studies in Natural Products. Hung-Wen (Ben) Liu, Tadhg P. Begley, Eds. Comprehensive Natural Products III, Chemistry and Biology. Elsevier Ltd. 2020.






 

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