殷伯翰 | 博士 | 教授 | 博士生导师 | |
科 室: | 药剂学实验室 | |||
办公电话: |
| 电子邮箱: | bohanyin@ouc.edu.cn | |
联系地址: | 山东省青岛市鱼山路5号中国海洋大学药物楼B307, 邮编266003 | |||
研究方向: | 1. 纳米材料与生物体的相互作用 2. 纳米基底材料调控细胞行为 3.纳米生物传感器 4. 纳米药物递送 | |||
个人简介 |
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教授,博士生导师。于2024年加入医药学院开展独立研究。主要探究不同修饰的纳米材料与生物体在器官、组织、细胞与分子等不同层面的相互作用,研发以纳米材料为基础的新型生物传感器用于检测病毒核酸,以及构建新型纳米载药平台用于疾病的检测与治疗。近年来,以第一/通讯作者的身份在Sci. Adv., Adv. Funct. Mater., ACS Nano, Nano Lett., Small, Theranostics等国际权威期刊上发表论文17篇。主持山东省优秀青年基金(海外)、山东省泰山学者青年专家和中国海洋大学青年英才工程第一层次基金等项目。课题组主页:https://www.dynanolab.com | ||||
教育背景 |
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2015.08~2020.03 | 香港中文大学 | 生物医学工程 | 博士 | |
2011.09~2015.07 | 中国农业大学 | 化学 | 学士 | |
工作经历 |
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2024~今 | 中国海洋大学医药学院 | 教授 |
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2021.01~2024.01 | 香港理工大学 | 博士后 |
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2020.04~2020.11 | 香港中文大学 | 研究助理 |
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学术兼职 |
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Royal Society of Chemistry 会员(MRSC) (2022~今) American Chemical Society 会员(MACS) (2023~今) Frontiers in Bioengineering and Biotechnology的审稿编辑 Frontiers in Molecular Biosciences, Frontiers in Bioengineering and Biotechnology 和International Journal of Molecular Sciences等期刊的审稿人。 | ||||
荣誉奖励 |
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1st Runner up of Hong Kong Medical and Healthcare Device Industries Association Student Research Awards(2019-2020)
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研究进展 |
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纳米材料的结构设计,纳米颗粒的表面修饰,以及基底材料修饰纳米结构,对于细胞活动(例如细胞内吞,外排,和力学信号传导等)的调控在体内和体外都发挥着至关重要的作用。本课题组(1)总结了纳米材料与生物体从个体层面到分子或受体层面的多层次的机理研究,发现了纳米颗粒的表面修饰细化到官能团层面不但影响细胞内吞和外排纳米颗粒,也会直接调控纳米颗粒在小鼠体内形成的蛋白质冕,引起的免疫反应,以及不同细胞类型内的分布;(2)发现了纳米级粗糙度的基底材料或纳米级同向分布的黏附配体可以通过上调胞吞作用相关的基因,增强clathrin的表达,进而显著增强细胞内吞纳米颗粒的能力;相反,纳米级异向分布的黏附配体同时招募integrin β1和β3,促进细胞黏附结构的发展、黏附依赖性信号通路的激活、干细胞分化用于组织工程;(3)研发了新型的诊疗平台用于靶向肿瘤,深入研究肿瘤细胞的运作机理,结合光学技术和协同疗法用于诊断和高效治疗肿瘤。
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代表性成果 | ||||
代表性论文(†equal contribution; *corresponding author; IF: 2023年影响因子): | ||||
1. Yin, B.; Chan, C. K. W.; Liu, S.; Wong, S. H. D.; Ho, L. W. C.; Zhang, L.; Leung, K. C. F.; Choi, P. C. L.; Bian, L.; Tian, X. Y.; Chan, M. N.; Choi, C. H. J. Intrapulmonary cellular-level distribution of inhaled nanoparticles with defined functional groups and its correlations with protein corona and inflammatory response. ACS Nano 2019, 13, 14048–14069. [IF=17.1] (納米人微信公众号推广-链接) 2. Wong, S.H.D.†; Yin, B.†; Li, Zhuo; Yuan, W.; Zhang, Q.; Xie, X.; Tan. Y.; Wong, N.; Zhang, K.; Bian, L, Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling, Sci. Adv.2023, 9, adg9593. [IF=13.6] 3. Yin, B.; Ho, W. K. H.; Xia, X.; Chan, C. K. W.; Zhang, Q.; Ng, Y. M.; Lam, C. Y. K.; Cheung, J. C. W.; Wang, J.; Yang, M.; Wong, S. H. D. A Multilayered mesoporous gold nanoarchitecture for ultraeffective near-infrared light-controlled chemo/photothermal therapy for cancer guided by SERS imaging. Small2023, 19, 2206762. [IF=13.3] [Hot Topic: Mesoporous Materials (Small)] [Hot Topic: Surfaces and Interfaces (Advanced Materials Interfaces)] [Selected for Frontispiece in (Small 6/2023) Link] (化学与材料科学微信公众号推广-链接) [highly cited paper in the top 1% of the academic field of Clinical Medicine (2022 ESI)] 4. Yin, B.; Zhang, Q.; Yan, J.; Huang, Y.; Li, C.; Chen, J.; Wen, C.; Wong, S. H. D.; Yang, M.Nanomanipulation of ligand nanogeometry modulates integrin/clathrin-mediated adhesion and endocytosis of stem cells. Nano Lett.2023,23, 9160–9169. [IF=10.8] 5. Wong, S. H. D.†;Yin, B.†; Lin, S.; Yang, B.; Li, R.; Feng, Q.; Yang, H.; Zhang, L.; Yang, Z.; Li, G.; Choi, C. H. J.; Bian, L. Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells. Adv. Funct. Mater.2019,29, 1806822. [IF=19.0] 6. Yin, B.†; Li, K. H. K.†; Ho, L. W. C.; Chan, C. K. W.; Choi, C. H. J. Toward understanding in vivo sequestration of nanoparticles at the molecular level. ACS Nano 2018, 12, 2088–2093.[IF=17.1] 7. Yin, B.†; Ho, L. W. C.†; Liu, S.; Hong, H.; Tian, X. Y.; Li, H.; Choi, C. H. J. Sub-10 nm substrate roughness promotes the cellular uptake of nanoparticles by upregulating endocytosis-related genes. Nano Lett.2021,21, 1839–1847. [IF=10.8] 8. Yin, B.; Zhang, Q.; Xia, X.; Li, C.; Ho, W. K. H.; Yan, J.; Huang, Y.; Wu, H.; Wang, P.; Yi, C.; Hao, J.; Wang, J.; Chen, H.; Wong S. H. D.; Yang, M.A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection.Theranostics2022, 12, 5914–5930. [IF=12.4] (Theranostics微信公众号推广-链接) 9. Yin, B.†; Ni, J.†; Witherel C. E.†; Yang, M.; Burdick, J. A.; Wen, C.; Wong, S. H. D. Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics. Theranostics2022, 12, 207. [IF=12.4] (Theranostics微信公众号推广-链接) [highly cited paper in the top 1% of the academic field of Clinical Medicine (2022 ESI)] 10. Yin, B.†; Ho, W. K. H.†; Zhang, Q.;Li, C.; Huang, Y.; Yan, J.; Yang, H.; Hao, J.; Wong S. H. D.; Yang, M. Magnetic-responsive surface-enhanced Raman scattering platform with tunable hot spot for ultrasensitive virus nucleic acid detection. ACS Appl. Mater. Interfaces2022,14, 4714–4724. [IF=9.5] 11. Yin, B.†; Ho, L. W. C.†, Choi, C. H. J. How Do Cells Exocytose Nanoparticles? Biochemistry, 2023,62, 2229–2231. [IF=2.9] 12. Ho, L. W. C.†; Yin, B.†; Dai, G.; Choi, C. H. J. Effect of surface modification with hydrocarbyl groups on the exocytosis of nanoparticles. Biochemistry2020,60, 1019–1030.[IF=2.9] 13. Wong, W. K.†; Yin, B.†; Lam, C. Y. K.;Huang, Y.; Yan, J.; Tan, Z.; Wong S. H. D. The interplay between epigenetic regulation and CD8+ T cell differentiation/exhaustion for T cell immunotherapy. Front. Cell Dev. Biol.2022, 9, 783227. [IF=5.5] 14. Yin, B; Wong, W.K.; Ng, Y.M.; Yang, M.; Leung, F.K.C.; Wong, S.H.D.,Smart Design of Nanostructures for Boosting Tumor Immunogenicity in Cancer Immunotherapy, Pharmaceutics2023,15, 1427. [IF=5.4] 15. Yin, B.; Yang, H.; Yang, M. Integrating soft hydrogel with nanostructures reinforces stem cell adhesion and differentiation. J. Compos. Sci.2022,6, 19. [IF = 3.3] 16. Yin, B.; Wu, Y.; Ma, H.; Ma, X.; Fu, B.; Liu, J. Studies on the asymmetric catalytic Friedel-Crafts alkylation of indoles with trifluoromethyl pyruvate catalyzed by heteroarylidene-BOX-Cu Complexes. Chin. J. Org. Chem.2015,35, 2119–2124. 17. Wong, W. K.†; Yin, B.†; Rakhmatullina A.; Zhou, J.; Wong, S. H. D. Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy. Eng. Regen.2021, 2, 70–81. | ||||
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