| 申传斌 | 博士 | 教授 | 博士生导师 | |||
科 室： | 药理学实验室 | ||||||
电子邮箱： | shenchuanbin@ouc.edu.cn | ||||||
联系地址： | 山东省青岛市鱼山路5号中国海洋大学医药学院266003 | ||||||
研究方向： | 1. 血小板和血栓性心脑血管病 2. 细胞黏附受体相关信号通路及靶向药物 3. 海洋先导化合物靶向筛选及分子药理学 | ||||||
个人简介 |
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2022年08月受聘于中国海洋大学“青年英才工程”第一层次教授岗位，加入医药学院开展独立研究。主要研究方向为血栓性心脑血管病发病机制，以及靶向细胞黏附受体的抗心脑血管病海洋生物新药研发。本研究团队具备完整的，从相关病理机制探索，到靶向药物分子发掘与设计，再到基于细胞和动物模型的药理及毒理学评价技术体系。近年来发表SCI论文26篇，其中以第一(含共一)/通讯作者在Blood, Nature immunology, Circulation Research, EBioMedicine, Thrombosis and Haemostasis, Cellular and Molecular Life Sciences, Archives of Toxicology, Toxins, Chinese Journal of Natural Medicines等顶尖和权威期刊发表研究论文。在新型抗血小板血栓先导化合物发掘与设计方向获授权国家发明专利3项。 | |||||||
教育背景 |
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2012.09~2017.07 | 中国科学院 | 昆明动物研究所 | 理学博士（硕博连读） | ||||
2008.09~2012.07 | 山东农业大学 | 生命科学学院 | 工学学士 | ||||
工作经历 |
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2022.08至今 | 中国海洋大学 | 医药学院 | 教授 | ||||
2019.11~2022.07 | 多伦多大学 | 基南生物医学科学研究中心 | 博士后研究员 | ||||
2017.07~2019.10 | 中科院昆明动物所 | 动物模型与人类疾病机理重点实验室 | 助理研究员 | ||||
学术兼职 |
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受邀担任Frontiers in Pediatrics 儿童血液学和恶性血液病专题客座编辑；Thrombosis and Haemostasis, Frontiers in immunology等期刊审稿人。 | |||||||
荣誉奖励 |
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研究进展 |
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血栓是高危心脑血管疾病（如心梗、脑梗）的一个主要病因。血小板在血栓形成尤其是动脉栓塞发生中不可或缺。αIIbβ3整合素是血小板及其前体细胞中特有的黏附受体。我们首次发现β3整合素、14-3-3ζ蛋白以及c-Src激酶形成复合体并在血小板激活和血栓形成中发挥关键作用。14-3-3ζ蛋白通过同时结合于β3整合素胞内“TST”结构域和c-Src的SH2结构域促进14-3-3ζ-c-Src-integrin-β3复合体的形成以及αIIbβ3整合素外向内的信号传导。针对此复合物设计发掘的抑制剂可以显著抑制血小板聚集、延展和血栓的形成，同时不会明显影响αIIbβ3与其胞外配体的结合。此研究为开发新型、低出血风险的抗血栓药物提供了新靶点和思路，同时也提供了一系列潜在的抗血小板/抗血栓先导分子。（相关一系列研究成果发表在Blood 2020, Thrombosis and Haemostasis 2020, Cardiovascular, Haematological Disorders-Drug Targets2020，Molecules 2021，并已被授权3项发明专利201710070868.2，202010805688.6，202010805686.7）。
基于天然生物药材的药用功能和生物的生存策略，从海洋生物及动物毒液/分泌物中定向发掘活性分子，并研究它们对血液和心脑血管系统的药理、毒理学作用。基于此技术体系分别筛选到了一系列具有抗血栓或促凝血等功能的生物分子。发现血小板膜糖蛋白激活和去唾液酸糖基化是部分毒素引起血栓性微血管病和血小板减少的新机制。为血栓性心脑血管病的防治提供了一系列的先导药物分子及模板，并为食/药用动植物资源活性成分开发和新型靶向药物的高效发掘提供了理论和技术支持。（相关一系列研究成果发表在Cellular and Molecular Life Sciences 2022，Blood 2021, Archives of Toxicology 2021，Scientific Reports 2021，Thrombosis and Haemostasis 2020，Toxins 2020，The international journal of biochemistry & cell biology 2014等）。
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代表性成果 | |||||||
代表性论文 | |||||||
1 Meiquan Li,Xiaopeng Tang,Zhiyi Liao,Chuanbin Shen,Ruomei Cheng,Mingqian Fang,Gan Wang, Ya Li,Shuzhen Tang, Li Xie,ZhiyeZhang, Peter Muiruri Kamau,James Mwangi,Qiumin Lu,Yaxiong Li, Yuming Wang,Daniel Thomas Mackeigan,Eric G. Cerenzia,Heyu Ni,Ren Lai. Hypoxia and low temperature up-regulate transferrin to induce hypercoagulability at high altitude. Blood2022, in press. 2 Zhiye Zhang, Chuanbin Shen(co-first author), Mingqian Fang, Yajun Han, Chengbo Long, Weihui Liu, Min Yang, Ming Liu, Dengdeng Zhang, Qiqi Cao, Xue Chen, Yaqun Fang, Qiumin Lu, Zongliu Hou, Yaxiong Li, Zhenze Liu, Xi Lei, Heyu Ni, Ren Lai. Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke. Cellular and Molecular Life Sciences 2022,79(5):240. 3 Chuanbin Shen, Ming Liu, Daniel Mackeigan, Ziyan Chen, Pingguo Chen, Danielle Karakas, June Li, Peter Norris, Jiayao Li, Yanling Deng, Chengbo Long, Ren Lai, Heyu Ni. Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: Novel mechanism and therapeutic strategy for venom-induced thrombocytopenia. Archives of Toxicology2021, 95(11): 3589-3599. 4 Ming Liu, Gan Wang, Runjia Xu, Chuanbin Shen, Heyu Ni, Ren Lai. Soy isoflavones inhibit both GPIb-IX signaling and αIIbβ3 outside-in signaling via 14-3-3ζ in platelet. Molecules 2021, 26(16): 4911. 5 Chuanbin Shen, Ming Liu, Runjia Xu, Gan Wang, June Li, Pingguo Chen, Wenjing Ma, James Mwangi, Qiumin Lu, Zilei Duan, Zhiye Zhang, Fatima Dahmani, Daniel Mackeigan, Heyu Ni, Ren Lai. The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. Blood2020, 136(8): 974-988. 6 Chuanbin Shen, Ming Liu, Huiwen Tian, Jiameng Li, Runjia Xu, James Mwangi, Qiumin Lu, Xue Hao, Ren Lai.Conformation-specific blockade of αIIbβ3 by a non-RGD peptide to inhibit platelet activation without causing significant bleeding and thrombocytopenia.Thrombosis and Haemostasis2020, 120(10): 1432-1441. 7 Chengbo Long, Ming Liu, Huiwen Tian, Ya Li, Feilong Wu, James Mwangi, Qiumin Lu, Abd El-Aziz Tarek Mohamed, Ren Lai, Chuanbin Shen (Corresponding author). Potential role of platelet-activating c-type lectin-like proteins in viper envenomation induced thrombotic microangiopathy symptom. Toxins 2020, 12(12):749. 8 Xiaopeng Tang, Mingqian Fang, Ruomei Cheng, Zhiye Zhang, Yuming Wang, Chuanbin Shen (co-first author), Yajun Han, Qiumin Lu, Yingrong Du, Yingying Liu, Zhaohui Sun, Liping Zhu, James Mwangi, Min Xue, Chengbo Long, Ren Lai. Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability. Circulation Research2020, 127(5): 651-663. 9 Daniel MacKeigan, Tiffany Ni, Chuanbin Shen, Tyler W. Stratton, Wenjing Ma, Guangheng Zhu, Preeti Bhoria, Heyu Ni. Updated understanding of platelets in thrombosis and hemostasis: the roles of integrin PSI domains and their potential as therapeutic targets. Cardiovascular & Haematological Disorders-Drug Targets 2020, 20(4): 260-273. 10 Huiwen Tian, Ming Liu, Jiameng Li, Runjia Xu, Chengbo Long, Hao Li, James Mwangi, Qiumin Lu, Ren Lai, Chuanbin Shen (Corresponding author). Snake c-type lectins potentially contribute to the prey immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri venoms. Toxins 2020, 12(2): 105. 11 Runjia Xu, Shuohan Fei, Linyan Chen, Gan Wang, Ming Liu, Wensheng Zhang,Xiuwen Yan, Ren Lai, Chuanbin Shen (Corresponding author). 3'-Methoxydaidzein exertsanalgesic activity by inhibiting voltage-gated sodium channels. Chinese Journal of Natural Medicines 2019, 17(6): 413-423. 12 Lin Jin, Xiaomin Guo, Chuanbin Shen (co-first author), Xue Hao, Peng Sun, Pengpeng Li, Tao Xu, Chunmiao Hu, Ombati Rose, Hongning Zhou, Mingdong Yang, Cheng-Feng Qin, Jingya Guo, Hua Peng, Mingzhao Zhu, Gong Cheng, Xiaopeng Qi, Ren Lai. Salivary factor LTRIN from Aedes Aegypti facilitates the transmission of zika virus by interfering with the lymphotoxin-β receptor.Nature Immunology 2018, 19(4):342-353. 13 Xiaoqin He, Chuanbin Shen (co-first author), Qiumin Lu, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong, Ren Lai. Prokineticin 2 plays a pivotal role in psoriasis. EBioMedicine2016, 13: 248-261. 14 Zhiye Zhang, Ping Meng, Yajun Han, Chuanbin Shen, Bowen Li, Md Abdul Hakim, Xuguang Zhang, Qiumin Lu, Mingqiang Rong, Ren Lai. Mitochondrial DNA-LL-37 complex promotes atherosclerosis by escaping from autophagic recognition. Immunity 2015, 43(6): 1137-1147. 15 Zhiye Zhang, Lan Gao, Chuanbin Shen, Mingqiang Rong, Xiuwen Yan, Ren Lai. A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands. The international journal of biochemistry & cell biology 2014, 54: 83-88. 学术报告及摘要
授权发明专利
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