进化与发育研究室

研究团队

进化与发育研究室

Laboratory for Evolution & Development
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进化与发育研究室
Laboratory for Evolution & Development
Team Leader: Prof. Shicui ZHANG

研究方向

进化与发育实验室（LED）是在我国著名学者童第周先生等于20世纪40年代创建的实验胚胎学实验室的基础上发展而来的。目前，实验室有7名教师，全部具有博士学位，其中山东省“泰山学者”2人，山东省有突出贡献专家1人，山东省优秀教师1人，山东省优秀科技工作者1人，教育部新世纪优秀人才2人。实验室与美国、日本、冰岛和泰国等国多家实验室建立了合作关系。主要研究方向：文昌鱼发育和进化生物学；鱼类发育和衰老机制。

研究队伍

张士璀 教授

E-mail: sczhang@ouc.edu.cn

Tel: 0532-82032787

Resume

刘振辉 教授

E-mail: zhenhuiliu@ouc.edu.cn

Tel: 0532-82032170

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李红岩 教授

E-mail: hongyanli@ouc.edu.cn

Tel: 0532-82032092

Resume

汲广东 讲师

E-mail: jamesdong@ouc.edu.cn

Tel: 0532-82031665

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孙晨副教授

E-mail: sunchen@ouc.edu.cn

Tel: 0532-82031365

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张宇副教授

E-mail: yuzhang@ouc.edu.cn

Tel: 0532-82031387

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高瞻副教授

E-mail: gaozhan@ouc.edu.cn

Tel: 0532-82032439

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承担课题

· 国家重点基础研究发展规划（973）项目1项

· 国家海洋863课题1项

· 国家联合基金项目1项

· 国家自然科学基金面上项目3 项

近期论文及成果

（一）主要论文（*通讯作者）

1. Li M, Gao Z, Ji D, *Zhang S.Functional Characterization of GH-Like Homolog in Amphioxus Reveals an Ancient Origin of GH/GH Receptor System.Endocrinology. 2014 Dec;155(12): 4818-30.

2. Liu S, Liu Y, Yang S, Huang Y, Qin Q, *Zhang S. Evolutionary conservation of molecular structure and antiviral function of a viral receptor, LGP2, in amphioxusBranchiostoma japonicum.Eur J Immunol.2015 Dec;45(12):3404-16.

3. Gao Z, Li M, Ma J, *Zhang S. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate.Eur J Immunol.2014 Dec;44(12):3680-95.

4. Liu M, *Zhang S.Amphioxus IGF-like peptide induces mouse muscle cell development via binding to IGF receptors and activating MAPK and PI3K/Akt signaling pathways.Mol Cell Endocrinol.2011 Aug 22;343(1-2):45-54.

5. Wang Y, *Zhang S. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and 'pre-hepatic' acute phase response.Funct Integr Genomics. 2011 Mar;11(1):111-8.

6. Wang S, *Zhang S, Zhao B, Lun L.Up-regulation of C/EBP by thyroid hormones: a case demonstrating the vertebrate-like thyroid hormone signaling pathway in amphioxus.Mol Cell Endocrinol.2009 Dec 10;313(1-2):57-63.

7. Fan C, *Zhang S, Liu Z, Li L, Luan J, Saren G.Identification and expression of a novel class of glutathione-S-transferase from amphioxusBranchiostoma belcheriwith implications to the origin of vertebrate liver.Int J Biochem Cell Biol.2007;39(2):450-61.

8. Li G, *Zhang S, Xiang J. Phenoloxidase, a marker enzyme for differentiation of the neural ectoderm and the epidermal ectoderm during embryonic development of amphioxus Branchiostoma belcheri tsingtaunese.Mech Dev.2000 Aug;96(1):107-9.

9. Liu H, Lei M, Du X, Cui P, *Zhang S. Identification of a novel antimicrobial peptide from amphioxusBranchiostoma japonicumbyin silicoand functional analyses.Sci Rep. 2015 Dec 18;5:18355.

10. Wang L, Wang Y, Li Z, Gao Z, *Zhang S.Functional characterization of protein 4.1 homolog in amphioxus: defining a cryptic spectrin-actin-binding site.Sci Rep.2013 Oct 7;3:2873.

11. Wang X, Du X, Li H, *Zhang S. Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections.J Biol Chem. 2016 Feb 19;291(8):4019-34.

12. Wang S, Wang Y, Ma J, Ding Y, *Zhang S.　Phosvitin Plays a Critical Role in the Immunity of Zebrafish Embryos via Acting as a Pattern Recognition Receptor and an Antimicrobial Effector.J Biol Chem.2011 Jun 24;286 (25):22653-64.

13. *Zhang S, Wang S, Li H, Li L.　Vitellogenin, a multivalent sensor and an antimicrobial effector.Int J Biochem Cell Biol.2011 Mar;43(3):303-5.

14. Hu L, Sun C, Wang S, Su F, *Zhang S.Lipopolysaccharide neutralization by a novel peptide derived from phosvitin.Int J Biochem Cell Biol.2013 Nov;45(11):2622-31.

15. *Zhang S, Wang Z, Wang H. Maternal immunity in fish.Dev Comp Immunol. 2013 Jan-Feb;39(1-2):72-8.

16. *Zhang S, Cui P. Complement system in zebrafish.Dev Comp Immunol.2014 Sep;46(1):3-10.

17. Lu L, Yuan J, *Zhang S.Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats.Age(Dordr). 2013 Jun;35(3):637-46.

18. Wang X, Chang Q, Wang Y, Su F, *Zhang S. Late-onset temperature reduction can retard the aging process in aged fish via a combined action of an anti-oxidant system and the insulin/insulin-like growth factor 1 signaling pathway.Rejuvenation Res. 2014 Dec;17(6):507-17.

19. Yuan J, Lu L, Zhang Z, *Zhang S. Dietary intake of resveratrol enhances the adaptive immunity of aged rats.Rejuvenation Res. 2012 Oct;15(5):507-15.

20. Liu C, Wang X, Feng W, Li G, Su F, *Zhang S. Differential expression of aging biomarkers at different life stages of the annual fishNothobranchius guentheri.Biogerontology. 2012 Oct;13(5):501-10.

（二）英文专著

1. Shicui Zhang, Haimanti Bhattacharya and Hongyan Li. Chapter 12 Embryogenesis and Development.In“Reproductive Biology and Phylogeny of Fishes (Agnathans and Bony fishes)” (Ed. by Barrie G.M. Jamieson), 2009. Science Publishers, Plymouth. Pages 485-517.

（三）教材

张红卫（主编）、王子仁和张士璀（副主编），《发育生物学》；2001年第一版，2006年第二版，2013年第三版；高等教育出版社，北京。

其他

本室所主持完成的成果先后获国家技术发明二等奖1项、山东省自然科学一等奖1项、教育部自然科学一等奖1项、国家海洋局海洋科技创新一等奖1项以及省部级二等奖多项。

导航

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