进化与发育实验室（Laboratory for Evolution & Development, LED）是在我国著名学者童第周先生等于20世纪40年代创建的实验胚胎学实验室的基础上发展而来的。目前，实验室有7名教师，其中山东省“泰山学者特聘教授”1人，全国模范教师1人，山东省有突出贡献专家1人，山东省优秀教师1人，山东省优秀科技工作者1人，教育部新世纪优秀人才3人。研究方向主要有：1）神经内分泌系统发育和演化 ；2）比较与进化免疫学；3）发育和衰老机制。

国家自然科学基金面上项目：锌指蛋白Znf296参与心肌细胞形成的转录后调控机制研究（2025-2028）

国家自然科学基金面上项目：垂体-甲状腺轴起源探索：文昌鱼促甲状腺素β亚基及其受体的相互作用和功能鉴定 （2023-2026）

国家自然科学基金面上项目：RNA结合蛋白Rbm20参与骨骼肌分化的转录后调控机制研究 （2022-2025）

国家自然科学基金面上项目：鱼卵中肝素结合蛋白的分离和功能分析：新的母源性免疫因子的鉴定 （2021-2024）

国家自然科学基金面上项目：体细胞高频突变机制起源探索：文昌鱼胞苷脱氨酶介导基因突变的功能研究 （2021-2024）

山东省自然科学基金面上项目：Bmp8a 通过 Nkx6.3 调控脂肪细胞分化的分子机制研究 （2023-2025）

山东省自然科学基金面上项目：锌指蛋白Znf296调控脑组织形成的机制研究 （2025-2027）

· 科研论文

1. Wang X, Li X, Wang Y, Ren Z, Du X, Gao J, Ji G, Liu Z. Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring). 2024 Jul;32(7):1315-1328.

2. Wei M, Yu Q, Li E, Zhao Y, Sun C, Li H, Liu Z, Ji G. Ace Deficiency Induces Intestinal Inflammation in Zebrafish. Int J Mol Sci. 2024 May 21;25(11):5598.

3. Wang Y, Lin J, Li W, Ji G, Liu Z. Identification, Expression and Evolutional Analysis of Two cyp19-like Genes in Amphioxus. Animals (Basel). 2024 Apr 9;14(8):1140.

4. Zhong S, Du X, Gao J, Ji G, Liu Z. BMP8B Activates Both SMAD2/3 and NF-κB Signals to Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. Nutrients. 2023 Dec 25;16(1):64. 

5. Chen L, Zhong S, Wang Y, Wang X, Liu Z, Hu G. Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. Int J Mol Sci. 2023 Sep 22;24(19):14444.

6. Gao Z, Jiang W, Zhang Y, Zhang L, Yi M, Wang H, Ma Z, Qu B, Ji X, Long H, Zhang S. Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA. Commun Biol. 2023 Jul 18;6(1):744.

7. Zhong S, Chen L, Li X, Wang X, Ji G, Sun C, Liu Z. Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation. Commun Biol. 2023 Aug 8;6(1):824. 

8. Yang S, Xu X, Zhang A, Wang Y, Ji G, Sun C, Li H. The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). Int J Biol Macromol. 2023 Jun 1;239:124214.

9. Xiao K, Song L, Li Y, Li C, Zhang S. Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri. Biogerontology. 2023 Apr;24(2):207-223.

10. Xiang K, He Z, Fu J, Wang G, Li H, Zhang Y, Zhang S, Chen L. Microplastics exposure as an emerging threat to ancient lineage: A contaminant of concern for abnormal bending of amphioxus via neurotoxicity. J Hazard Mater. 2022 Sep 15;438:129454.

11. Li X, Guo R, Yang S, Zhang X, Yin X, Teng L, Zhang S, Ji G, Li H. Cd248a and Cd248b in zebrafish participate in innate immune responses. Front Immunol. 2022 Aug 31;13:970626. 

12. Zhou Y, Ni S, Li C, Song L, Zhang S. Gonadal Rejuvenation of Mice by Growth Differentiation Factor 11. J Gerontol A Biol Sci Med Sci. 2022 May 5;77(5):892-901.

13. Yang S, Zhang X, Li X, Yin X, Teng L, Ji G, Li H. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Int J Mol Sci. 2022 Jul 7;23(14):7523.

14. Gong Y, Li H, Wu F, Li Y, Zhang S. Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo. Biomolecules. 2022 Jul 10;12(7):965.

15. Wu F, Gong Y, Song L, Li H, Zhang X, Li H, Zhang S. In vitro and in vivo wound healing-promoting activities of phosvitin-derived peptide Pt5-1c. Eur J Pharmacol. 2022 Apr 5;920:174833.

16. Song L, Wu F, Li C, Zhang S. Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway. Biogerontology. 2022 Jun;23(3):341-362.

17. Song L, Li C, Wu F, Zhang S. Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production. Biogerontology. 2022 Apr;23(2):201-213. 

18. Li C, Song L, Zhou Y, Yuan J, Zhang S. Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity. Biogerontology. 2022 Feb;23(1):99-114.

19. Ni S, Zhou Y, Song L, Chen Y, Wang X, Du X, Zhang S. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection. Commun Biol. 2021 Feb 26;4(1):251. 

20. Zhong S, Li H, Wang YS, Wang Y, Ji G, Li HY, Zhang S, Liu Z. Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Commun Biol. 2021 Mar 9;4(1):318.

21. Chen C, Yuan J, Ji G, Zhang S, Gao Z. Amphioxus ribosomal proteins RPS15, RPS18, RPS19 and RPS30-precursor act as immune effectors via killing or agglutinating bacteria. Fish Shellfish Immunol. 2021 Nov;118:147-154. 

22. Song L, Yuan J, Ni S, Zhou Y, Wang X, Chen Y, Zhang S. Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity. Mol Immunol. 2020 Jan;117:160-167. 

· 英文专著

1. Gao Z, Zhang S. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology” (Ed. by Edwin L. Cooper), 2018. Springer International Publishing AG, Switzerland. Pages 593-635.

2. Li H, Zhang S. Functions of Vitellogenin in Eggs. In “Oocytes Maternal Information and Functions” (Ed. by Malgorzata Kloc), 2017. Springer International Publishing AG, Switzerland. Pages 389-401.

3. Shicui Zhang, Haimanti Bhattacharya and Hongyan Li. Chapter 12. Embryogenesis and Development. In “Reproductive Biology and Phylogeny of Fishes (Agnathans and Bony fishes)” (Ed. by Barrie G.M. Jamieson), 2009. Science Publishers, Plymouth. Pages 485-517.

· 中文专著和教材

1. 张士璀（总主编），《中国珍稀濒危海洋生物》科普丛书（共5册）；2024年第一版，中国海洋大学出版社

2. 张士璀，《文昌鱼演化生物学：追溯脊椎动物起源》；2020年第一版，科学出版社，北京。

3. 张士璀何建国孙世春（主编），《海洋生物学》；2017年第一版，中国海洋大学出出版社，青岛。

4. 张士璀马军英范晓（主编），《海洋生物技术原理和应用》；1997年第一版，海洋出版社

5. 张红卫（主编）、王子仁和张士璀（副主编），《发育生物学》；2001年第一版，2006年第二版，2013年第三版，高等教育出版社，北京。

本实验室主持完成的成果先后获国家技术发明二等奖1项、山东省自然科学一等奖1项、教育部自然科学一等奖1项、国家海洋局海洋科技创新一等奖1项以及省部级二等奖多项。