研究方向：

　　针对海洋药用生物物种多样性与代谢多样性，聚焦于中国南海珊瑚礁生态系统中具有代表性的珊瑚、海绵等低等无脊椎动物及其共生微生物，开展其次级代谢产物分离鉴定、合成与结构优化、生物活性及其作用机制等研究。主要包括：

（1）海洋药用生物与环境因子的耦合关系，探讨代谢产物的生源关系及其作为药物的分子基础。

（2）基于海洋真菌的天然产物的分离提取、结构鉴定、活性评价与生物合成途径研究。

（3）海洋天然产物的全合成、优势骨架利用、成药性优化与作用机制探讨。

（4）针对肿瘤、炎症、神经系统等重大疾病发生发展过程关键靶蛋白，进行分子靶向药物设计合成。

国家自然科学基金面上项目（2022-2026）

国家自然科学基金面上项目（CW, 2025-2028）

国家自然科学基金面上项目（PW, 2025-2028）

山东省“泰山学者”青年专家计划（ZL, 2022-2025）

山东省“泰山学者”青年专家计划（PW, 2022-2025）

山东省自然科学基金青年项目（2025-2027）

Li J.-F.#, Chen B.#, Fu Z.-Y.#, Mao J.-J.#, Liu L.-J., Chen X.-C., Zheng M.-Y., Wang C.-Y.*, Guo Y.-W.*, Xu B.-F.*. Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility. Nat. Commun., 2024, 15: 5940.

Zhou Y.#, He N.#, Liu Q., Li R., Yang L.-J., Kang W., Zhang X.-X., Xu X.-Y., Yao G.-S., Wang P., Wang C.-Y.*, Yang J.-B.*, Liu Z.*. Structural optimization of marine natural product pretrichodermamide B for the treatment of colon cancer by targeting JAK/STAT3 signaling pathway. J. Med. Chem., 2024, 67, 10783-10794.

Kang W.#, Gao S.-S.#, Bao J.-P., Yang L.-J., Ma Y.-Q., Wang P., Wang C.-Y.*, Cui C.-S.*. Synthetic nicotinamide cofactors as alternatives to NADPH in imine reductase-catalyzed reactions. Org. Lett., 2024, 26: 7817-7821.

Zheng Y.-Y., Mao J.-Q., Liu Y., Han N., Lv L., Zhang Y.-H., Chen M., Liu Z.-Q., Shao C.-L., Yao G.-S.*, Wang C.-Y.*. Pleiotropically activation of azaphilone biosynthesis by overexpressing a pathway-specific transcription factor in marine-derived Aspergillus terreus RA2905. Bioorg. Chem., 2024, 153; 107832.

Yang L.-J., Lv L., Han Z., Gu Y.-C., Li X., Shao C.-L., Liu Z.* Wang C.-Y.*. Penijanacoranes A-F, acorane-type sesquiterpenes from a deep sea-derived fungus Penicillium janthinellum SH0301. Chinese J. Chem., 2024, ASAP, DOI***

Han N., Zheng Y.-Y., Jia Y.-N., Feng J.-Z., Huang J.-Z., Huang J.-H., Wang C.-Y.*, Yao G.-S.*. Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin. Microb. Cell Fact., 2024, 23:134.

Zhang Y.-H., Du H.-F., Liu Y.-F., Cao F.*, Luo D.-Q.*, Wang C.-Y.*. Novel anti-inflammatory diketopiperazine alkaloids from the marinederived fungus Penicillium brasilianum. Appl. Microbiol. Biot., 2024, 108: 194.

Wang P.*, Lv L., Li H.-R., Wang C.-Y.*, Zhou J.*. Opportunities and challenges in drug discovery targeting the orphan receptor GPR12. Drug Discov. Today, 2023, 28(9):103698.

Lv L.#, Maimaitiming M #, Huang Y.#, Yang J.-C., Chen S.-X., Sun Y.-F., Zhang X.-T., Li X., Xue C.-H., Wang P.*, Wang C.-Y.*, Liu Z.*. Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur. J. Med. Chem., 2023, 254, 115346.

Wang P.#^,*, Zhu W.-T.#, Wang Y., Song S.-S., Xi Y., Yang X.-Y., Shen Y.-Y., Su Y., Sun Y.-M., Gao Y.-L., Chen Y., Ding J., Miao Z.-H., Zhang A., He J.-X.*. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023, 259, 115709.

Li R.#, Zhou Y.#, Zhang X.-X., Yang L.-J., Liu J.-Y., Wightman S. M., Lv L., Liu Z.*, Wang C.-Y.*, Zhao C.-Y.*. Identification of marine natural product pretrichodermamide B as a STAT3 inhibitor for efficient anticancer therapy. Mar. Life Sci. Technol., 2023, 5:94–101.

Maimaitiming M., Lv L., Zhang X., Xia S., Li X., Wang P.*, Liu Z.*, Wang C.-Y.*. Semi-Synthesis and Biological Evaluation of 25(R)-26-Acetoxy-3β,5α-Dihydroxycholest-6-One. Mar Drugs. 2023, 21, 191.

Ma Z.-L.#, Yu Z.-P.#, Yao-Yao Zheng Y.-Y., Han N., Zhang Y.-H., Song S.-Y., Mao J.-Q., Li J.-J., Yao G.-S.*, Wang C.-Y.*. Bioactive alpha-pyrone and phenolic glucosides from the marine-derived Metarhizium sp. P2100. J. Fungi, 2023, 9, 28.

Li H.-X.#, Ouyang S.-M.#, Zhang Y., Peng K.-R., Fang W., Liu Z.*, Wang C.-Y.*, Zhang X.-L.*, Wang Y.-X.*. Structural optimization of imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway. Eur. J. Med. Chem., 2022, 244, 114858.

Chen B.#, Qiu P.-J.#, Xu B.-F.#, Zhao Q.-M., Gu Y.-C., Fu L., Bi S.-J., Lan L.-F.*, Wang C.-Y.*, Guo Y.-W.*. Cytotoxic and antibacterial isomalabaricane terpenoids from the sponge Rhabdastrella globostellata. J. Nat. Prod., 2022, 85: 1799−1807.

Sun X.-Y., Zhu J.-X., Liu C.-Q., Wang D.-F., Wang C.-Y.*. Fabrication of fucoxanthin/2-hydroxypropyl-ß-cyclodextrin inclusion complex assisted by ultrasound procedure to enhance aqueous solubility, stability and antitumor effect of fucoxanthin. Ultrason. Sonochem., 2022, 90: 106215.

Zhao Q.#, Song S.-Y.#, Zhang Y.-Q., Ren X., Zhang P., Li X., Fu X.-M., Wang C.-Y.*. The underlying mechanisms of anti-hepatitis B effects of formula Le-Cao-Shi and its single herbs by network pharmacology and gut microbiota analysis. Biomed. Pharmacother., 2022, 148: 112692. 

Liu Z.*, Wang P., E. A. Wold, Song Q.-L., Zhao C.-Y., Wang C.-Y.*, Zhou J.*. Small-molecule inhibitors targeting the canonical WNT signaling pathway for the treatment of cancer. J. Med. Chem., 2021, 64, 4257-4288.

Chen B., Huan X.-J, Miao Z.-H, Voogd N.-J. D., Gu Y.-C., Wang C.-Y.*, Guo Y.-W*, Li X.-W.*. Uncommon bis-quinolizidine alkaloids from the Hainan sponge Neopetrosia chaliniformis. Chin. J. Chem., 2021, 39, 1838-1842.

Wu J.-S., Meng Q.-Y., Zhang Y.-H., Shi X.-H., Fu X.-M., Zhang P., Li X., Shao C.-L.*, Wang C.-Y.*. Annular oxygenation and rearrangement products of cryptotanshinone by biotransformation with marine-derived fungi Cochliobolus lunatus and Aspergillus terreus. Bioorg. Chem., 2020, 103, 104192.

Wu J.-S.#, Meng Q.-Y.#, Shi X.-H., Liu L.-X., Zhang Z.-K., Guan H.-S., Shao C.-L.*, Wang C.-Y.*. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg. Chem., 2020,104, 104246; doi.org/10.1016/j.bioorg.2020.104246

Liu Y.-F., Zhang Y.-H., Shao C.-L., Cao F.*, Wang C.-Y.*. Microketides A and B, polyketides from a gorgonian-derived Microsphaeropsis sp. fungus. J. Nat. Prod., 2020, 83: 1300-1304. 

Zhang M.-Q., Ren X., Zhao Q., Yue S.-J., Fu X.-M., Li X., Chen K.-X., Guo Y.-W., Shao C.-L.*, Wang C.-Y.*. Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity. J. Ethnopharmacol., 2020, 256, 112795.