主要从事海洋微生物技术与应用研究，近年来主要研究方向为
（1）海洋微生物化学信号通讯与互作
（2）海洋微生物环境适应与生态效应
（3）海洋微生物应用技术-聚焦防治病虫害新策略
（4）海洋微生物与抗菌新资源的机制与发掘利用
王岩 教授 博士生导师
E-mail: wangy12@ouc.edu.cn
Tel:0532-82031517
主要研究方向及成果：
海洋资源微生物多样性与开发；细菌遗传及群体感应与群体感应淬灭的调控机制。研究成果在PLoS Genetics，ACS Synthetic Biology，Applied and Environmental Microbiology，Journal of Bacteriology等领域内高水平杂志发表，授权专利1项；入选2016年中国科协“青年人才托举工程”，获得2014年山东省优秀博士论文。
Dr. Yan WANG:
Professor
Honors and Awards:
Young elite scientists sponsorship program by CAST (2016), Excellent PHD thesis of shandong province in 2014.
Research Interest:
Microbial diversity and development of Marine resources,The regulation of bacterial quorum sensing and quorum quenching.
（1）国家自然科学基金面上项目：信号分子吲哚乙酸调控产酶溶杆菌跨界互作的机制研究（2024-2027）
（2）国家自然科学基金面上项目：海洋抗菌肽TPAD的效用机制及其与细菌信号通路抑制剂的协同抗菌作用（2022-2025）
（3）国家自然科学基金面上项目：吲哚抑制细菌耐药性的新型机制研究（2019-2022）
（4）国家自然科学基金面上项目：新型密度感应淬灭酶MomL的作用机制及其在植物细菌性病害防治中的应用（2016-2019）
（5）国家自然科学基金青年项目：深海新菌深渊藤黄单胞菌新型α-淀粉酶的温度适应性机制研究（2016-2018）
（6）山东省泰山学者青年项目（2021-2025）
（7）中国海洋大学创新交叉团队培育计划“海洋微生物技术与医用材料工程”（2024-2026）
2023 Zhang R, Wang Y. EvgS/EvgA, the unorthodox two-component system regulating bacterial multiple resistance. Applied and Environmental Microbiology 89(12): e0157723.
2023 Zhu Y, Dou Q, Du L, Wang Y. QseB/QseC: a two-component system globally regulating bacterial behaviors. Trends in Microbiology 31(7): 749-762.
2023 Dou Q, Zhu Y, Li C, Bian Z, Song H, Zhang R, Wang Y, Zhang X, Wang Y. 4F-indole enhances the susceptibility of Pseudomonas aeruginosa to aminoglycoside antibiotics. Microbiology Spectrum 11(2).
2023 Cao Q, Ge C, Wang X, Harvey PJ, Zhang Z, Ma Y, Wang X, Jia X, Mobli M, Craik DJ, Jiang T, Yang J, Wei Z, Wang Y, Chang S, Yu R. Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics 24(2), bbad058.
2022 Zhu Y, Han Y, Liu G, Bian Z, Yan X, Li Y, Long H, Yu G, Wang Y. Novel indole-mediated potassium ion import system confers a survival advantage to the Xanthomonadaceae family. The ISME Journal 16(7), 1717-1729.
2022 Zhong J, Yan X, Zuo X, Zhao X, Yang J, Dou Q, Peng L, Zhu Y, Xiao Y, Bian Z, He D, Xu Q, Wright S, Li Y, Du L, Wang Y, Yuan J. Developing a new treatment for superficial fungal infection using antifungal collagen-HSAF dressing. Bioengineering & Translational Medicine 7(3), e10304.
2022 Wang Y, Bian Z, Wang Y. Biofilm formation and inhibition mediated by bacterial quorum sensing. Applied Microbiology and Biotechnology 106(19-20), 6365-6381.
2022 Xing M, Wang Y, Zhao Y, Chi Z, Chi Z, Liu G. C-terminal bacterial immunoglobulin-like domain of κ-carrageenase serves as a multifunctional module to promote κ-carrageenan hydrolysis. Journal of Agricultural and Food Chemistry 70(4), 1212-1222.
2022 Li Y, Feng T, Wang Y. The role of bacterial signaling networks in antibiotics response and resistance regulation. Marine Life Science & Technology 4, 163-178.
2022 Song H, Li Y, Wang Y. Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors. Engineering Microbiology 10, 466084.
2022 Dou Q, Yuan J, Yu R, Yang J, Wang J, Zhu Y, Zhong J, Long H, Liu Z, Wang X, Li Y, Xiao Y, Liang J, Zhang X, Wang Y. MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway. mLife 1(4): 428-442。
2021 Liu J, Zhou H, Yang Z, Wang H, Chen H, Zhong L, Zheng W, Niu W, Wang S, Ren X, Zhong G, Wang Y, Ding X, Müller R, Zhang Y, Bian X. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria. Nature Communications 12(1), 4347.
2020 Yang Y, Yue Y, Song N, Li C, Yuan Z, Wang Y, Ma Y, Li H, Zhang F, Wang F, Jia H, Li F, Li X, Wang Q, Ding Z, Dong H, Gu L, Li B. The YdiU domain modulates bacterial stress signaling through UMPylation. Cell Reports 32(12), 108161.
2020 Yu R, Wang J, So L, peta J. harvey, Shi J, Liang J, Dou Q, Li X, Yan X, Huang Y, Xu Q, Kaas Q, Chow H, Wong K, Craik D, Zhang X, Jiang T, Wang Y. Enhanced activity against multi-drug resistant bacteria through coapplication of an analogue of Tachyplesin I and an inhibitor of the QseC/B signaling pathway. Journal of Medicinal Chemistry 63(7), 3475-3484.
2020 Han Y, Wang Y, Yang Y, Chen H. Shellmycin A-D, Novel bioactive tetrahydroanthra-γ-pyrone antibiotics from marine Streptomyces sp. Shell-016. Marine Drugs 18(1), 58.
2019 Wang Y, Tian T, Zhang J, Jin X, Yue H, Zhang X, Du L, Bai F. Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer. mBio 10(3), e00676-19.
2019 Feng T, Han Y, Li B, Li Z, Yu Y, Sun Q, Li X, Du L, Zhang X, Wang Y. Interspecies and intraspecies signals synergistically regulate Lysobacter enzymogenes twitching motility. Applied and Environmental Microbiology 85(23), e01742-19.
2019 Wang Y, Feng Y, Li H, Yu Y, Han Y, Zhang J, Li X, Li Y, Zhang X. A novel heterologous expression strategy of quorum quenching enzyme MomL in Lysobacter enzymogenes to inhibit pathogenicity of Pectobacterium. Applied Microbiology and Biotechnology 103(21-22), 8889-8898.
2019 Wang J, Lin J, Zhang Y, Zhang J, Feng T, Hui Li, Wang X, Sun Q, Zhang X and Wang Y. Activity improvement and vital amino acid identification on the marine-derived quorum quenching enzyme MomL by protein engineering. Marine Drugs 17(5), 300.
2019 Zhang J, Wang J, Feng T, Du R, Tian X, Wang Y and Zhang X. Heterologous expression of the marine-derived quorum quenching enzyme MomL can expand the antibacterial spectrum of Bacillus brevis. Marine Drugs 17(2), 128.
专利
一种新型α-淀粉酶及其应用，20150205474.4 已授权
一种异源表达群体感应淬灭酶的方法，201710314231.3 已授权
一种用于农作物病害防治的重组菌株，201710314232.8 已授权
一种用于病害防治的高活力蛋白的构建方法与应用，201810260812.8 已授权
一种提高天然产物生物合成量的方法，ZL202110047419.2 已授权
一株海洋来源菌株及其在线虫防治中的应用，ZL202210075732.1 已授权
一种基于抑制细菌毒力释放的降低抗生素用量的方法与应用，201910016646.1
吲哚在制备抑制黄单胞菌科细菌抗生素耐药性药物中的应用，201910911477.8
一种具有拮抗线虫功效的蛋白酶，202410839828.X
一种抗真菌水解酶及其应用，2024108397361
地址：青岛市鱼山路5号 中国海洋大学达尔文馆 邮编: 266003Tel/Fax: +86 532 8203 1982
Ocean University of China, Yushan Campus, No. 5 Yushan Road,Qingdao 266003,China,E-mail: zhangc@ouc.edu.cn
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