动物胚胎发育和成体器官再生的过程包含了“细胞命运的决定”以及“相关形态结构构建”两个相对独立却相互影响的过程。细胞信号转导是细胞命运决定过程中关键的调控机制：靶细胞通过受体接收信号细胞分泌出来的配体分子，引发其胞内的信号级联反应，最终诱导该细胞向特定命运分化。在细胞命运决定的同时，细胞通过改变其行为，驱动组织层面上的变化，逐步形成预定的结构。

本实验室以果蝇和斑马鱼为主要模式生物，结合遗传学、组学、分子生物学、显微成像与定量分析等现代技术，系统研究Hedgehog、Notch、JNK等多种重要发育信号的相互交织决定细胞命运的分子机理，以及细胞命运决定之后的细胞行为驱动胚胎发育以及器官（心脏）再生的作用机理。

Animal embryonic development and organ regeneration are driven by the signaling network-controlled cell fate determination and cell-shape-based tissue morphogenesis.  The target cells receive ligand molecules secreted by the signaling cell, which triggers an intracellular signaling cascade that ultimately induces the cell to differentiate toward a specific fate. While the cell's fate is being determined, interactions between cell-cell contacts, remodeling of the cytoskeleton, together with the cell number control system, collectively define tissue morphology, gradually forming the intended structure. 

Using Drosophila and zebrafish as the main model organisms, our laboratory focuses on how the interwoven signaling pathways, such as Hedgehog, Notch, and JNK, control embryo development and organ (mainly heart) regeneration in terms of cell fate determination, and how cellular behavior drives tissue morphogenesis. 

·        中国海洋大学“筑峰人才工程”启动经费

·        中国海洋大学“青年英才工程”启动经费

·        国家自然科学基金面上项目4项，青年项目1项

本科生课程：

《细胞生物学》理论（40课时，2.5学分，春季学期，水产学院；赵龙，独立讲授）

《分子生物学》理论（双语，48课时，3学分，春季学期，海德学院；苏颖，与其他两位老师合讲）

《模式生物发育与进化》理论（32课时，2.5学分，春季学期，全校通识课；苏颖、赵龙，参与讲授）

研究生课程

《发育分子生物学》，苏颖、赵龙，参与讲授

《高级生物化学》，赵龙，参与讲授

*通讯作者，^#共同一作

1.        Fang Y^#, Zhang F^#, Zhao F, Wang J, Cheng X, Ye F, He J, Zhao L*, Su Y*. (2024) RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis. Science China Life Sciences doi:10.1007/s11427-024-2646-3

2.        Zhang F^#, Luo W^#, Liu S^#, Zhao L*, Su Y*. (2024) Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands. FEBS Journal doi:10.1111/febs.17247

3.        Luo W^#, Zhang F^#, Zhao F, Fang Y, Zhao L*, Su Y*. (2024) Dual role of PpV in Drosophila crystal cell proliferation and survival. Journal of Molecular Cell Biology doi:10.1093/jmcb/mjae028

4.        Xu D, Pan J, Fang Y, Zhao L*, Su Y*. (2024) RpS25 is required for sperm elongation and individualization during Drosophila spermatogenesis. Biochemical and Biophysical Research Communications 702:149633.

5.        Fang Y^#, Zhang F^#, Zhan Y^#, Lu M, Xu D, Wang J, Li Q, Zhao L*, Su Y*. (2023) RpS3 is required for spermatogenesis of Drosophila melanogaster. Cells 12(4):573.

6.        Lu M^#, Hayat R^#, Zhang X^#, Jiao Y, Huang J, Huangfu Y, Jiang M, Fu J, Jiang Q, Gu Y, Wang S, Akerberg A, Su Y*, Zhao L*. (2023) Comparative analysis of the cardiac structure and transcriptome of scallop and snail, perspectives on heart chamber evolution. Marine Life Science & Technology 5(4): 478-491.

7.        Zhang M^#, Liu C^#, Zhao L, Zhang X*, Su Y*. (2023) The emerging role of protein phosphatase in regeneration. Life (Basel) 13(5):1216.

8.        Luo W, Liu S, Zhang F, Zhao L*, Su Y*. (2022) Metabolic strategy of macrophages under homeostasis or immune stress in Drosophila. Marine Life Science & Technology 4(3): 291-302.

9.        Liu M^#, Su Y^#, Peng J, Zhu AJ. (2021) Protein modifications in Hedgehog signaling: Cross talk and feedback regulation confer divergent Hedgehog signaling activity. Bioessays Nov 5: e2100153.

10.      Gan T, Fan L, Zhao L, Misra M, Liu M, Zhang M*, Su Y*.(2021) JNK signaling in Drosophila aging and longevity. International Journal of Molecular Sciences 22(17): 9649.

11.      Zhao L^#, Gao F ^#, Gao S ^#, Liang Y ^#, Long H ^#, Lv Z ^#, Su Y^#, Ye N ^#, Zhang L ^#, Zhao C ^#, Wang X, Song W, Zhang S, Dong B. (2021) Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms. Science China Life Sciences 64(8): 1236-1280.

12.      Gao J, Fan L, Zhao L*, Su Y*. (2021) The interaction of Notch and Wnt signaling pathways in vertebrate regeneration. Cell Regeneration 10(1): 11.

13.      Liu M, Liu A, Wang J, Zhang Y, Li Y, Su Y*, Zhu AJ*. (2021) Competition between two phosphatases fine-tunes Hedgehog signaling. Journal of Cell Biology 220(2): e202010078.

14.      Lan W, Liu S, Zhao L*, Su Y*. (2020) Regulation of Drosophila hematopoiesis in lymph gland: from a developmental signaling point of view. International Journal of Molecular Sciences 21: 5246.

15.      赵又佼，赵龙*，苏颖* (2020) 锌离子、锌转运蛋白-细胞信号通路的新调控因子。中国细胞生物学学报42(9): 1631-1641.

16.      Zhao L, Ben-Yair R, Burns CE, Burns CG. (2019) Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism. Cell Reports 26(3): 546-554.

17.      Galvez-Santisteban M, Chen D, Zhang R, Serrano R, Nguyen C, Zhao L, Nerb L, Masutani EM, Vermot J, Burns CG, Burns CE, del Alamo JC, Chi NC. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLife 8:e44816.

18.      Wang L, Yang J*, Wang H, Ran C, Su Y, Zhao L*. (2019) A highly selective turn-on fluorescent probe detection of aluminum and its application to bio-imaging. Sensors 19(11): 2423.

19.      Chi C, Wang L, Lan W, Zhao L*, Su Y*. (2018) PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing. Apoptosis23: 554-562.

20.      Zhao L, Wang L, Chi C, Lan W, Su Y*. (2017) The emerging roles of phosphatases in Hedgehog pathway. Cell Communication and Signaling 15: 35.

21.      Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, and Chi NC. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature 534: 700-704.

22.      Jahangiri L, Sharpe M, Novikov N, González-Rosa JM, Borikova A, Nevis K, Paffett-Lugassy N, Zhao L, Adams M, Guner-Ataman B, Burns CE, Burns CG. (2015) The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development 143: 113-122.

23.      Mahmoud A, O’Meara C, Gemberling M, Zhao L, Bryant DM, Zheng RM, Gannon JB, Cai L, Choi WY, Egaczyk GF, Burns CG, Burns CE, Macrae CA, Poss KD, Lee RT. (2015) Nerves regulate cardiomyocyte proliferation and heart regeneration. Developmental Cell 34: 387-399.

24.      Harrison MR, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF and Lien CL. (2015) Chemokine guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell 33(4): 442-454.

25.      Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Schlaeger TM, Zon LI, Gigas A, Burns CE, Daley G. (2015) Notch1 acts via Foxc2 to induce the endothelial to hematopoietic transition during embryonic development. Blood 125(9): 1418-1426.

26.      Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, Macrae CA, Lee RT, Burns CG, Burns CE. (2014) Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. PNAS 111(4): 1403-1408.

27.      Su Y^#, Ospina JK^#, Zhang J^#, Michelson A, Schoen AM, Zhu AJ. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling 4: ra43.

28.      Tian T^#, Zhao L^#, Zhang M, Zhao XY, Meng AM. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochemical and Biophysical Research Communications 380(3): 537-542.

29.      Zhao L^#, Zhao XY^#, Tian T^#, Lu QL, Nirma Skrbo-Larssen, Wu D, Kuang Z, Zheng XF, Han YC, Yang SY, Zhang CM, Meng AM. (2008) Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research 80(2): 200-208.

30.      Su Y^#, Zhang L^#, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen Y. (2007) The evolutionally conserved activities of Dapper2 in antagonizing TGF-b signaling. FASEB Journal 21: 682-690.

31.      Lin X^#, Duan X^#, Liang Y^#, Su Y^#, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen Y, Meng A, Feng X. (2006) PPM1A functions as a Smad phosphatase to terminate TGFb signaling.Cell125: 915-928.

32.      Zhang L^#, Zhou H^#, Su Y^#, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen Y, Meng A. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science306: 114-117.