进化与发育实验室（Laboratory for Evolution & Development, LED）是在我国著名学者童第周先生等于20世纪40年代创建的实验胚胎学实验室的基础上发展而来的。目前，实验室有8名教师，其中山东省“泰山学者特聘教授”1人，全国模范教师1人，山东省有突出贡献专家1人，山东省优秀教师1人，山东省优秀科技工作者1人，教育部新世纪优秀人才3人。

        研究方向主要有：1、神经内分泌系统/免疫系统发育和演化 ；2、发育和衰老机制。

· 在研的国家自然科学基金面上项目4项：

1. 脊椎动物肝脏起源探索：文昌鱼肝盲囊的免疫-代谢互相作用与调控研究

2. 垂体-甲状腺轴起源探索：文昌鱼促甲状腺素β亚基及其受体的相互作用和功能鉴定

3. CRIP1在胚胎血管发育中的功能和作用机制研究

4. LRRFIP1不同剪切体在斑马鱼早期胚胎肌肉发育中的功能和作用机制

· 在研的国家重点研发计划“蓝色粮仓”项目2项：

1. 病原诱导的先天免疫信号通路与调控网络

2. 宿主免疫效应因子与抗感染免疫稳态调控

· 代表性论文

Part 1, Amphioxus & EvoDevo

1. Liang Y, Rathnayake D, Huang S, Pathirana A, Xu Q, Zhang S. BMP signaling is required for amphioxus tail regeneration. Development. 2019 Feb 15;146(4).

2. Wang P, Wang M, Zhang L, Zhong S, Jiang W, Wang Z, Sun C, Zhang S, Liu Z. Functional characterization of an orexin neuropeptide in amphioxus reveals an ancient origin of orexin/orexin receptor system in chordate. Sci China Life Sci. 2019 Dec;62(12):1655-1669.

3. Wang P, Liu S, Yang Q, Liu Z, Zhang S. Functional Characterization of Thyrostimulin in Amphioxus Suggests an Ancestral Origin of the TH Signaling Pathway. Endocrinology. 2018 Oct 1;159(10):3536-3548.

4. Wang P, Wang M, Ji G, Yang S, Zhang S, Liu Z. Demonstration of a Functional Kisspeptin/Kisspeptin Receptor System in Amphioxus With Implications for Origin of Neuroendocrine Regulation. Endocrinology. 2017 May 1;158(5):1461-1473.

5. Li M, Gao Z, Ji D, Zhang S. Functional Characterization of GH-Like Homolog in Amphioxus Reveals an Ancient Origin of GH/GH Receptor System. Endocrinology. 2014 Dec;155(12): 4818-30.

6. Liu S, Liu Y, Yang S, Huang Y, Qin Q, Zhang S. Evolutionary conservation of molecular structure and antiviral function of a viral receptor, LGP2, in amphioxus Branchiostoma japonicum. Eur J Immunol.2015 Dec;45(12):3404-16.

7. Gao Z, Li M, Ma J, Zhang S. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. Eur J Immunol.2014 Dec;44(12):3680-95.

Part 2, Development& Immunity

1. Wang S, Ji D, Yang Q, Li M, Ma Z, Zhang S, Li H. NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish. J Cell Physiol. 2019 Jul;234(7):11208-11218.

2. Ni S, Zhou Y, Chen Y, Du X, Zhang S. Identification of ATP synthase α subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection. FASEB J. 2019 Nov;33(11):12983-13001.

3. Du X, Zhou Y, Song L, Wang X, Zhang S. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. FASEB J. 2018 Feb;32(2):979-994.

4. Wang X, Du X, Li H, Zhang S. Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections. J Biol Chem. 2016 Feb 19;291(8):4019-34.

5. Li HY, Grifone R, Saquet A, Carron C, Shi DL. The Xenopus homologue ofDown syndrome critical region protein 6 drives dorsoanterior gene expression and embryonic axis formation by antagonising polycomb group proteins. Development. 2013, 140(24):4903-13.

6. Wang S, Wang Y, Ma J, Ding Y, Zhang S.Phosvitin Plays a Critical Role in the Immunity of Zebrafish Embryos via Acting as a Pattern Recognition Receptor and an Antimicrobial Effector. J Biol Chem. 2011 Jun 24;286 (25):22653-64.

Part 3, Aging & Anti-aging

1. Song L, Yuan J, Ni S, Zhou Y, Wang X, Chen Y, Zhang S. Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity. Mol Immunol. 2020 Jan;117:160-167. 

2. Zhou Y, Song L, Ni S, Zhang Y, Zhang S. Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system. Biogerontology. 2019 Aug;20(4):433-443.

3. Zhou Y, Ni S, Song L, Wang X, Zhang Y, Zhang S. Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri. Biogerontology. 2019 Apr;20(2):225-239.

4. Wang X, Chang Q, Wang Y, Su F, Zhang S. Late-onset temperature reduction can retard the aging process in aged fish via a combined action of an anti-oxidant system and the insulin/insulin-like growth factor 1 signaling pathway. Rejuvenation Res. 2014 Dec;17(6):507-17.

5. Wang X, Shang X, Luan J, Zhang S. Identification, expression and function of apolipoprotein E in annual fish Nothobranchius guentheri: implication for an aging marker. Biogerontology. 2014 Jun;15(3):233-43

6. Lu L, Yuan J, Zhang S. Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats. Age (Dordr). 2013 Jun;35(3):637-46. 

· 英文专著

1. Gao Z, Zhang S. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology” (Ed. by Edwin L. Cooper), 2018. Springer International Publishing AG, Switzerland. Pages 593-635.

2. Li H, Zhang S. Functions of Vitellogenin in Eggs. In “Oocytes Maternal Information and Functions” (Ed. by Malgorzata Kloc), 2017. Springer International Publishing AG, Switzerland. Pages 389-401.

3. Shicui Zhang, Haimanti Bhattacharya and Hongyan Li. Chapter 12. Embryogenesis and Development. In“Reproductive Biology and Phylogeny of Fishes(Agnathans and Bony fishes)” (Ed. by Barrie G.M. Jamieson), 2009. Science Publishers, Plymouth. Pages 485-517.

· 教材

1. 张士璀，《文昌鱼演化生物学：追溯脊椎动物起源》；2020年第一版，科学出版社，北京。

2. 张士璀何建国孙世春（主编），《海洋生物学》；2017年第一版，中国海洋大学出出版社，青岛。

3. 张红卫（主编）、王子仁和张士璀（副主编），《发育生物学》；2001年第一版，2006年第二版，2013年第三版，高等教育出版社，北京。

    本实验室主持完成的成果先后获国家技术发明二等奖1项、山东省自然科学一等奖1项、教育部自然科学一等奖1项、国家海洋局海洋科技创新一等奖1项以及省部级二等奖多项。