曹海岩,博士,副教授
邮箱:caohaiyan@ouc.edu.cn
学习工作经历:
2010-2014,南京农业大学生命科学学院,学士,生物科学(基地)
2014-2019,山东大学微生物技术研究院,博士,微生物学
2019-2023,山东大学微生物技术研究院,博士后
2023-至今,中国海洋大学海洋生命学院,副教授
主要科研领域:
主要从事海洋微生物参与的海洋有机碳、硫的代谢与循环,以及发挥重要生物学功能的蛋白的结构与功能研究。目前主持科研项目:国家自然科学基金青年基金,42206156,SAR11细菌二甲基巯基丙酸内盐转运载体的鉴定、结构解析及其适应寡营养环境的机制,2023.01-2025.12;山东省自然科学基金青年项目,ZR2021QC102,海洋 SAR11 细菌类群 DMSP 转运载体的鉴定及其适应寡营养环境的机制,2022.01-2024.12。
代表性成果:(#共同第一;*通讯作者)
C. Y. Li#, H. Y. Cao#*, Q. Wang, O. Carrión, X. Zhu, J. Miao, P. Wang, X. L. Chen, J. D. Todd, Y. Z. Zhang. Aerobic methylation of hydrogen sulfide to dimethylsulfide in diverse microorganisms and environments. ISME J, 17(8), 1184–1193 (2023).
Q. D. Zhang#, H. Y. Cao#, L. Wei, D. R. Lu, M. Du, M. Yuan, D. L. Shi, X. X. Chen, P. Wang, X. L. Chen, L. L. Chi, Y. Z. Zhang*, F. C. Li*, Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat. Commun. 12 (2021).
Y. Q. Zhang#, S. Zhang#, M. L. Sun, H. N Su, H. Y. Li, K. Liu, Y. Z. Zhang, X. L. Chen, H. Y. Cao*, X. Y. Song*, Antibacterial activity of peptaibols from Trichoderma longibrachiatum SMF2 against Gram-negative Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight on rice. Front. Microbiol.(2022).
H. Y. Cao, P. Wang, M. Peng, X. Shao, X. L. Chen, C. Y. Li*, Crystal structure of the dimethylsulfide monooxygenase DmoA from Hyphomicrobium sulfonivorans. Acta Crystallogr. F 74, 781-786 (2018).
P. Wang#, H. Y. Cao#, X. L. Chen, C. Y. Li, P. Y. Li, X. Y. Zhang, Q. L. Qin, J. D. Todd, Y. Z. Zhang*, Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol. Microbiol. 105, 674-688 (2017).
X. Shao, H. Y. Cao, F. Zhao, M. Peng, P. Wang, C. Y. Li, W. L. Shi, T. D. Wei, Z. Yuan, X. H. Zhang, X. L. Chen, J. D. Todd, Y. Z. Zhang, Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol. Microbiol. 111, 1057-1073 (2019).