律倩倩 ,博士,副教授
邮箱:lyuqianqian@ouc.edu.cn
承担课程:
本科生《生物化学》、《酶工程》
研究生《结构生物学与生物物理学》
学习工作经历:
2006~2010,山东建筑大学市政与环境工程学院,学士,生物工程专业
2010~2015,中国海洋大学海洋生命学院,博士, 生物化学与分子生物专业
2015~2018,中国海洋大学海洋生命学院,博士后
2019至今,中国海洋大学海洋生命学院,副教授
主要科研领域:
主要从事新型海洋糖苷酶的发掘与作用分子机制研究。以功能性海洋寡糖的开发为导向,发掘褐藻胶裂解酶、壳聚糖酶、糖基转移酶等不同类型的海洋糖苷酶,借助酶的空间结构研究,从分子水平揭示其作用机制,据此开发可用于功能性海洋寡糖制备的酶制剂。目前主持承担了国家自然科学基金,山东省自然科学基金等项目。相关研究成果发表在本领域权威期刊或申请专利,部分成果已转化。
代表性成果:(#共同第一;*通讯作者)
(1) Zhang Keke; Li Zhijian; Zhu Qiaoyun; Cao Huansheng; He Xinxin; Zhang Xiao-hua; Liu
Weizhi*; Lyu Qianqian*; Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements, Commun Biol, 2022, 5(1): 782
(2) Zhang Keke; Liu Tao; Liu Weizhi*; Lyu Qianqian*; Structural insights into the substratebinding cleft of AlyF reveal the first long-chain alginate-binding mode, Acta Crystallogr D Struct Biol, 2021, 7(Pt3): 336-346
(3) Zhang Keke; Yang Yan; Wang Weidong; Liu Weizhi*; Lyu Qianqian*; Substrate-Binding Mode and Intermediate-Product Distribution Coguided Protein Design of Alginate Lyase AlyF for Altered End-Product Distribution, J Agric Food Chem, 2021, 69: 7190-7198
(4) Lyu Qianqian; Zhang Keke; Shi Yanhong; Li Weihua; Diao Xiaotong; Liu Weizhi*; Structural insights into a novel Ca2+-independent PL-6 alginate lyase from Vibrio OU02 identify the possible subsites responsible for product distribution, Biochim Biophys Acta Gen Subj, 2019, 1863(7):1167-1176
(5) Lyu Qianqian; Zhang Keke; Zhu Qiaoyun; Li Zhijian; Liu Yujie; Fitzek Elisabeth; Yohe Tanner; Zhao Liming; Li Weihua; Liu Tao; Yin Yanbin; Liu Weizhi*; Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes, Biochim Biophys Acta Gen Subj, 2018, 1862(9): 1862-1869
(6)刘伟治; 律倩倩; 张柯柯; 刘玉杰; 朱巧云, 一种均一性褐藻寡糖的制备方法, 2017.6.9, 中国, 201710430426.4 专利号:ZL 2017 1 0430426.4
(7)Oligosaccharides of Chitin and Chitosan:Bio-manufacture and Applications, Springer, (chapter 3: Preparation of Chitooligosaccharides and Its Monomer),P27-54. Weizhi Liu*, Qianqian Lyu, Zhen, Qin