李春阳 ，博士，教授
邮箱：Lcy@ouc.edu.cn
电话：0532-8590 5528
承担课程：
微生物学
微生物酶学与生物地球化学
学习工作经历：
2007~2011，山东大学生命科学学院，学士，生物科学专业（生物学基地班）
2011~2016，山东大学生命科学学院，博士, 微生物学专业
2016~2018，山东大学微生物技术国家重点实验室，博士后
2018~2022，中国海洋大学海洋生命学院，“青年英才工程”第三层次副教授
2022至今，中国海洋大学海洋生命学院，“青年英才工程”第一层次教授
主要科研领域：
主要利用分子生物学、生物化学和结构生物学的技术方法研究海洋细菌代谢海洋中重要有机物，驱动碳、氮、硫元素生物地球化学循环的结构基础和分子机制。（1）发现海洋中代谢全球碳、硫循环的重要载体物质--二甲基巯基丙酸内盐（DMSP）的新型微生物类群，探究DMSP的代谢多样性；（1）解析DMSP合成及代谢过程中关键酶的结构并研究其催化分子机制；（3）探究海洋微生物代谢海洋氮循环中重要参与者甲基胺类物质的分子机制。已在国内外主流刊物发表论文四十余篇，成果发表在Nature Communications, PNAS, ISME J, eLife，Trends in Microbiology等国际权威期刊上。主持承担了国家重点研发计划项目课题、国家自然科学基金面上项目等项目课题；入选山东省泰山学者青年专家，并获国家首批“博士后创新人才支持计划”支持。
代表性成果：（#共同第一；*通讯作者）
(1) Ming Peng#; Chun-Yang Li#*; Xiu-Lan Chen; Beth T. Williams; Kang Li; Ya-Nan Gao; Peng Wang; Ning Wang; Chao Gao; Shan Zhang; Marie C. Schoelmerich; Jillian F. Banfield; J. Benjamin Miller; Nick E. Le Brun; Jonathan D. Todd*; Yu-Zhong Zhang*; Insights into methionine S-methylation in diverse organisms, Nat Commun, 2022, 13: 2947.
(2) Chun-Yang Li#*, Michaela A Mausz#, Andrew Murphy#, Nan Zhang# et al. Ubiquitous occurrence of a dimethylsulfoniopropionate ABC transporter in abundant marine bacteria. ISME J. 2023 17(4): 579–587.
(3) Chun-Yang Li#, Hai-Yan Cao#*, Qing Wang, et al. Aerobic methylation of hydrogen sulfide to dimethylsulfide in diverse microorganisms and environments. ISME J. 2023. 17(8):1184-1193
(4) Chun-Yang Li#, Xiu-Juan Wang#, Xiu-Lan Chen, et al. A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA. eLife. 2021 10:e64045. (被eLife Digest特别报道)
(5) Chun-Yang Li, Hai-Yan Cao, Andrew R.J. Curson, Peng Wang, Jonathan D. Todd, Yu-Zhong Zhang. Dimethylsulfoniopropionate and its catabolites are important chemical signals mediating marine microbial interactions. Trends Microbiol. 2023. 31(10):992-994.
(6) Zhao-Jie Teng#, Qi-Long Qin#, Weipeng Zhang,….Yin Chen*, Chun-Yang Li*. Biogeographic traits of dimethyl sulfide and dimethylsulfoniopropionate cycling in polar oceans. Microbiome. 2021 9(1):207.
(7) Chun-Yang Li, Tian-Di Wei, Sheng-Hui Zhang, et al. Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide. Proc Natl Acad SciUSA.2014 111(3):1026-1031.
(8) Ning Wang, Xiu-Lan Chen, Chao Gao,…. Chun-Yang Li*, Crystal structures of γ-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine. J Biol Chem. 2021 296:100081. (入选“Editors’ Picks”)
(9) Shu-Yan Wang, Nan Zhang, Zhao-Jie Teng, Xiao-Di Wang, Jonathan D. Todd, Yu-Zhong Zhang, Hai-Yan Cao, Chun-Yang Li*, A new dimethylsulfoniopropionate lyase of the cupin superfamily in marine bacteria. Environ Microbiol, 2023, 25(7):1238-1249
(10) Chun-Yang Li#, Jason C. Crack#, Simone Newton-Payne#, Andrew R. J. Murphy, Xiu-Lan Chen, Benjamin J. Pinchbeck, Shun Zhou, Beth T. Williams, Ming Peng, Xiao-Hua Zhang, Yin Chen, Nick E. Le Brun*, Jonathan D. Todd*, Yu-Zhong Zhang*. Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB. mLife. 2022; 1:114–130. (封面故事)
