高瞻，博士，副教授
邮箱：gaozhan@ouc.edu.cn
承担课程：
衰老生物学
学习工作经历：
2006.9-2010.6，中国海洋大学，生物科学专业，学士
2010.9-2015.6，中国海洋大学，海洋生物学专业，博士
2015.9-2018.12，中国海洋大学，海洋生命学院，讲师
2019.1至今，中国海洋大学，海洋生物多样性与进化研究所/海洋生命学院，副教授
主要科研领域：
主要从事免疫学、衰老生物学研究，近年来聚焦文昌鱼等重要进化节点生物，探究免疫系统关键组分的起源与演化。主持承担了国家自然科学基金面上项目、青年项目等课题。
代表性成果：（#共同第一；*通讯作者）
Gao Zhan#,*, Jiang Wanyue#, Zhang Yu#, Zhang Liping, Yi Mengmeng, Wang Haitao, Ma Zengyu, Qu Baozhen, Ji Xiaohan, Long Hongan, Zhang Shicui*. Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA. Communications Biology, 2023, 6:744.
Qu Baozhen, Zhang Shicui, Ma Zengyu, Gao Zhan*. Hepatic cecum: a key integrator of immunity in amphioxus. Marine Life Science & Technology, 2021, 3:279-292.
Chen Chaoyi, Yuan Jianrui, Ji Guangdong, Zhang Shicui, Gao Zhan*. Amphioxus ribosomal proteins RPS15, RPS18, RPS19 and RPS30-precursor act as immune effectors via killing or agglutinating bacteria. Fish and Shellfish Immunology, 2021, 118: 147-154.
Ma Zengyu, Tan Yunxia, Qu Baozhen, Gao Zhan*, Zhang Shicui*. Identification of amphioxus protein disulfide isomerase as both an enzyme and an immunocompotent factor. Developmental and Comparative Immunology, 2021, 126:104238.
Ma Zengyu, Qu Baozhen, Zhong Shenjie, Yao Lan, Gao Zhan*, Zhang Shicui*. Subtle Difference Generates Big Dissimilarity: Comparison of Enzymatic Activity in KL1 and KL2 Domains of Lancelet Klotho. Marine Biotechnology, 2019, 21(4):448-462.
Gao Zhan, Qu Baozhen, Yao Lan, Ma Zengyu, Zhang Shicui*. Identification and functional characterization of amphioxus Miple, ancestral type of vertebrate midkine/pleiotrophin homologues.Developmental & Comparative Immunology, 2018, 89:31-43.
Gao Zhan, Zhang Shicui*. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology” (Ed. by Edwin L. Cooper), 2018. Springer. Pages 593-636.
Gao Zhan, Ma Zengyu, Qu Baozhen, Jiao Deyan, Zhang Shicui*. Identification and characterization of properdin in amphioxus: Implications for a functional alternative complement pathway in the basal chordate. Fish & Shellfish Immunology, 2017, 65:1-8.
Gao Zhan,Qu Baozhen, Ma Zengyu, Jiao Deyan, Ji Guangdong*, Zhang Shicui*. Identification and functional characterization of a novel member of low density lipoprotein receptor-related protein (LRP)-like family in amphioxus. Gene, 2017, 618:42-48.
Gao Zhan, Li Mengyang, Ma Jie, Zhang Shicui*. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. European Journal of Immunology, 2014, 44(12): 3680-3695.
