师资队伍

苏颖

发布者：杨光发布时间：2024-09-23浏览次数：16053




苏颖，博士，教授/博导

邮箱：suying@ouc.edu.cn

电话：0532-82031916

实验室网站：https://iemb.ouc.edu.cn/18979/list.htm

承担课程：分子生物学


学习工作经历：

1997-2001   清华大学 生物科学与技术系，学士

2001-2006   清华大学 生物科学与技术系，博士

2006-2011   美国克利夫兰医学中心 勒纳研究所，博士后

2011-2014   美国克利夫兰医学中心 勒纳研究所，Research Associate

2014-2015   美国布朗大学，Assistant Professor

2016至今    中国海洋大学 海洋生命学院/海洋生物多样性与进化研究所，英才一岗教授


主要科研领域：

主要从事细胞信号调控器官发育的分子机制研究。利用斑马鱼和果蝇模式动物，鉴定细胞谱系形成和器官发生发育过程中的重要调控因子及信号通路，解析信号通路的关键成员及转导途径，探索动物发育过程中的内在分子调控机制。以首作者或通讯作者身份已在Science、Cell、Science Signaling、Journal of Cell Biology、FASEB Journal、Science China Life Sciences等领域内主流刊物上发表的论文二十余篇，论文他引近千次。

目前主要在研方向包括：1）造血器官发育及血细胞谱系发生的调控机理；2）生殖细胞分化成熟过程中重要调控因子的鉴定及功能、机制研究；3）蛋白质翻译后修饰在发育信号转导途径中的功能解析。


代表性成果：（#共首作者；*通讯作者）

  1. Fang Y#, Zhang F#, Zhao F, Wang J, Cheng X, Ye F, He J, Zhao L*, Su Y*. (2024) RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis. Science China Life Sciences doi:10.1007/s11427-024-2646-3

  2. Zhang F#, Luo W#, Liu S#, Zhao L*, Su Y*. (2024) Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands. FEBS Journal doi:10.1111/febs.17247

  3. Luo W#, Zhang F#, Zhao F, Fang Y, Zhao L*, Su Y*. (2004) Dual role of PpV in Drosophila crystal cell proliferation and survival. Journal of Molecular Cell Biology doi:10.1093/jmcb/mjae028

  4. Xu D, Pan J, Fang Y, Zhao L*, Su Y*. (2024) RpS25 is required for sperm elongation and individualization during Drosophila spermatogenesis. Biochemical and Biophysical Research Communications 702:149633.

  5. Fang Y#, Zhang F#, Zhan Y#, Lu M, Xu D, Wang J, Li Q, Zhao L*, Su Y*. (2023) RpS3 is required for spermatogenesis of Drosophila melanogaster. Cells 12(4):573.

  6. Luo W#, Liu S#, Zhang F, Zhao L*,Su Y*. (2022) Metabolic strategy of macrophages under homeostasis or immune stress in Drosophila. Marine Life Science & Technology 4(3): 291-302.

  7. Gan T#, Fan L#, Zhao L, Misra M, Liu M, Zhang M*, Su Y*.(2021) JNK signaling in Drosophila aging and longevity. International Journal of Molecular Sciences 22(17): 9649.

  8. Liu M#, Liu A#, Wang J#, Zhang Y, Li Y, Su Y*, Zhu AJ*. (2021) Competition between two phosphatases fine-tunes Hedgehog signaling. Journal of Cell Biology 220(2): e202010078.

  9. Chi C, Wang L, Lan W, Zhao L*,Su Y*. (2018) PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing. Apoptosis23: 554-562.

  10. Su Y#, Ospina JK#, Zhang J#, Michelson A, Schoen AM, Zhu AJ*. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling 4: ra43.

  11. Su Y#, Zhang L#, Gao X, Meng F, Wen J, Zhou H, Meng A*, Chen Y*. (2007) The evolutionally conserved activities of Dapper2 in antagonizing TGF-beta signaling. FASEB Journal 21: 682-690.

  12. Lin X#, Duan X#, Liang Y#, Su Y#, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen Y, Meng A, Feng X*. (2006) PPM1A functions as a Smad phosphatase to terminate TGF-beta signaling.Cell125: 915-928.

  13. Zhang L#, Zhou H#, Su Y#, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen Y*, Meng A*. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science306: 114-117.



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