姓名：刘雅
职称：教授/博导
邮箱：yaliu @ouc.edu.cn
地址：山东省青岛市鱼山路5号中国海洋大学科学馆210
科研领域：生物医用材料的研发与组装调控，主要包括：生物合成、纳米技术、药物递送、肿瘤治疗、组织工程、过度免疫治疗等。
学习工作简历：
2022年12月-2023年12月：新加坡国立大学 访问学者
2014年4月—至今：中国海洋大学 海洋生命学院 讲师 副教授 教授
2012年8月—2014年1月：国家纳米科学中心 联合培养
2008年9月—2013年6月：中国海洋大学 海洋生命学院 海洋生物学专业 博士
科研项目与奖励：
主持国家自然科学基金、青岛海洋科学与技术试点国家实验室前沿技术自由探索项目、山东省自然科学基金、中国博士后基金特别资助、中国博士后科学面上基金、青岛市自主创新应用专项、青年教师专项基金等；获得山东省优秀学位论文指导教师、山东省自然科学学术创新奖、山东省优秀博士学位论文、山东省研究生优秀科技创新成果奖、中国海洋大学第十四届优秀博士学位论文一等奖等多项学术奖励。
代表性成果
一．发表论文：
1. Ya Liu , Di Zhang , Zeng-Ying Qiao , Guo-Bin Qi , Xing-Jie Liang , Xi-Guang Chen*, Hao Wang*. A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy. Advanced Materials 27 (2015) 5034–5042
2. Ya Liu, Li-Li Li, Guo-Bin Qi, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Dynamic Disordering of Co-Assemblied Liposomal Cocktails: Spatio-Temporal Controlled Release of Cargoes to Circumvent Drug Resistance. Biomaterials 35 (2014) 3406-3415.
3. Ya Liu, Fu-Ping Gao, Di Zhang, Yun-Shan Fan, Xi-Guang Chen*, Hao Wang*. Molecular Structural Transformation Regulated Dynamic Disordering of Supramolecular Vesicles as pH-Responsive Drug Release Systems. Journal of Controlled Release 173 (2014) 140–147.
4. Ya Liu, Xiguang Chen*, Hao Wang, Nanoplatform containing MMPs-sensitive peptide-PEG conjugate and tissue-penetrating moiety for enhanced cancer therapy. Journal of Controlled Release 2017, 259, e162-e163.
5. Ya Liu*, Pei-Pei Yang, Zeng-Ying Qiao, Hao Wang and Xi-Guang Chen*. Tumor Microenvironmental pH and Enzyme Dual Responsive Polymer-Liposomes for Synergistic Treatment of Cancer Immuno-Chemotherapy.Biomacromolecules 2019, 20, 882−892.
6. Zhuang Teng#, Jianke Yang#, Xiguang Chen, Ya Liu*. Intranasal Morphology Transformation Nanomedicines for Long-Term Intervention of Allergic Rhinitis. ACS Nano 2023, https://doi.org/10.1021/acsnano.3c08752.
7. Pengsheng Fan#, Yinghua Guan#, Xiaoying Zhang, Jiaqi Wang, Yinsheng Xu, Benli Song, Suling Zhang, Hao Wang, Ya Liu*, Zeng-Ying Qiao*. Cell membrane-specific self-assembly of peptide nanomedicine induces tumor immunogenic death to enhance cancer therapy. Nanoscale Horizons, 2023, 8, 1226.
8. Lingyang Meng, Zhuang Teng, Shuang Yang, Na Wang, YingHua Guan, Xiguang Chen, Ya Liu *. Biomimetic nanoparticles for DC vaccination: a versatile approach to boost cancer immunotherapy. Nanoscale, 2023, 15, 6432.
9. Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu*. Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy. Biomaterials 282 (2022) 121434
10.Di Qin#, Andi Zhang#, Na Wang, Yingxia Yao, Xiguang Chen, Ya Liu*. Hydroxybutyl chitosan/ oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds. Applied Materials Today 26 (2022) 101342.
11. Ting Wang#, Zheng He#, Cong-Shan Yuan, Zhen-Wei Deng, Fang Li, Xi-Guang Chen, Ya Liu*. MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy. Journal of Controlled Release 343 (2022) 765-776.
12.Meng-jie Sun#, Zhuang Teng#, Peng-sheng Fan, Xi-guang Chen, Ya Liu*. Bridging micro/nano-platform and airway allergy intervention. Journal of Controlled Release 341 (2022) 364-382.
13. Cong-Shan Yuan#, Zhuang Teng#, Shuang Yang#, Zheng He, Ling-Yang Meng, Xi-Guang Chen, Ya Liu*. Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy. Journal of Controlled Release 351 (2022) 255-271.
14. Zhuang Teng, Ling-Yang Meng, Jian-Ke Yang, Zheng He, Xi-Guang Chen, Ya Liu*. Bridging nanoplatform and vaccine delivery, a landscape of strategy to enhance nasal immunity. Journal of Controlled Release 351 (2022) 456-475.
15. Di Qin#, Na Wang#, Xin-Guo You, An-Di Zhang, Xi-Guang Chen*, Ya Liu*. Collagen-based biocomposites inspired by bone hierarchical structures for advanced bone regeneration: ongoing research and perspectives. Biomaterials Science 2022, 10, 318-353.
16. Zhen-Wei Deng, Cong-Shan Yuan, Ting Wang, Xi-Guang Chen, Ya Liu*. Peptide-based assemblies as immune checkpoint inhibitor delivery systems for enhanced immunotherapy. Applied Materials Today23 (2021) 101063.
17. Mengjie Sun#, Di Qin#, Pengsheng Fan, Xiguang Chen, Ya Liu*. Chitosan-centered nanosystems as sustained therapeutics for allergic rhinitis intervention: Inhibition of histamine-induced cascades. Journal of Controlled Release335 (2021) 422-436.
18. Mei-Ping Tian, An-Di Zhang, Ying-Xia Yao, Xi-Guang Chen, Ya Liu*. Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing. Carbohydrate Polymers 261 (2021) 117878.
19. Cong-Shan Yuan, Zhen-Wei Deng, Di Qin, Yu-Zhi Mu, Xi-Guang Chen, Ya Liu*. Hypoxia-modulatory nanomaterials to relieve tumor hypoxic microenvironment and enhance immunotherapy: Where do we stand? Acta Biomaterialia 125 (2021) 1–28.
20. Yingxia Yao, Andi Zhang, Congshan Yuan, Xiguang Chen, Ya Liu*. Recent trends on burn wound care: hydrogel dressings and scaffolds. Biomaterials Science 2021, 9, 4523.
21. Peng-Sheng Fan#, Meng-Jie Sun#, Di Qin, Cong-Shan Yuan, Xi-Guang Chen, Ya Liu*. Nanosystems as curative platforms for allergic disorder management. Journal of Materials Chemistry B. 2021, 9, 1729-1744.
22. Andi Zhang#, Ya Liu#, Di Qin, Mengjie Sun, Ting Wang, Xiguang Chen*. Research status of self-healing hydrogel for wound management: A review. International Journal of Biological Macromolecules 164 (2020) 2108–2123.
23. Mengjie Sun, Ting Wang, Jianhui Pang, Xiguang Chen, Ya Liu*. Hydroxybutyl Chitosan Centered Biocomposites for Potential Curative Applications: A Critical Review. Biomacromolecules. 2020, 21, 1351-1367.
24. Xuqian Lang, Ting Wang, Mengjie Sun, Xiguang Chen, Ya Liu*. Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review. International Journal of Biological Macromolecules 154 (2020) 433-445.
25. Congshan Yuan#, Ya Liu#, Ting Wang, Mengjie Sun, and Xiguang Chen*. Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy. ACS Biomaterials Science & Engineering2020, 6, 4774–4798.
26. Zhenwei Deng, Ting Wang, Xiguang Chen, Ya Liu*. Applications of chitosan based biomaterials: a focus on dependent antimicrobial properties. Marine Life Science & Technology2, (2020) 398–413
27. Mengjie Sun, Xiaoping Yu, Ting Wang, Shichao Bi, Ya Liu*, Xiguang Chen*. Nasal adaptive chitosan-based nano-vehicles for anti-allergic drug delivery. International Journal of Biological Macromolecules 135 (2019) 1182-1192
28. Ting Wang, Fangqin Wang, Mengjie Sun, Meiping Tian, Yuzhi Mu, Xiguang Chen, Ya Liu*. Gastric environment-stable oral nanocarriers for in situ colorectal cancer therapy. International Journal of Biological Macromolecules 139 (2019) 1035-1045.
二．专利
1.陈西广，秦迪，程晓杰，孔明，刘雅，冯超. 一种鱼鳞基质骨修复材料的制备方法及应用.国家发明专利、申请号：202211209835.9
2.刘雅，张安迪，陈西广. 一种兼具自愈性和黏附性的复合水凝胶的制备方法，国家发明专利、申请号：201911245875.7
3.刘雅，孙梦杰，陈西广, 程晓杰, 孔明, 冯超. 一种兼具抑制组胺释放与组胺受体拮抗功能的纳米颗粒的制备方法, 国家发明专利、申请号201811503207.5
4.刘雅, 田美平, 陈西广, 程晓杰, 孔明, 冯超. 一种具有黏附性和抑菌性的温敏性水凝胶的制备方法, 国家发明专利、申请号201711409615.X
5.刘雅, 夏桂雪, 陈西广, 程晓杰, 孔明, 冯超.一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法, 国家发明专利、申请号201610884477.X
6.刘雅, 王方勤,陈西广,程晓杰, 孔明,冯超.一种pH 温度双敏感性壳聚糖纳米颗粒的制备方法, 国家发明专利、申请号201610884478.4
