何治宇/Zhiyu He | ||||||
职称： | 教授/博士生导师 |
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办公电话： | 无 | |||||
个人邮箱： | hezhiyu@ouc.edu.cn | |||||
地址： | 中国海洋大学崂山校区海化楼203室 | |||||
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研究领域或方向： | ||||||
(1)新型功能高分子聚合物开发（药物输送材料）； (2)多功能、高载药、靶向、缓/控释、微环境响应型纳米药物递送载体开发；
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(3)应用于脑中风、急性器官损伤、败血症、糖尿病等疾病防治的纳米药物制 剂的开发与应用 | ||||||
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教育经历： | ||||||
(1) 2014-08 至 2017-06, 中山大学中山医学院, 基础医学, 医学博士 导师：美国工程院院士/美国国家医学院院士 Kam. W Leong (2) 2011-08 至 2014-07, 浙江工业大学药学院, 药理学, 医学硕士 (3) 2007-08 至 2011-07, 蚌埠医学院药学院, 临床药学, 医学学士 | ||||||
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工作经历： |
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(1) 2020-03 至今, 中国海洋大学, “英才工程”第一层次，教授/博士生导师 (2) 2017-06至2020-01, 约翰霍普金斯大学医学院, 博士后研究员 (3) 2010-06 至 2011-06, 解放军总医院 (301医院), 药学部, 实习生 | ||||||
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学术兼职： |
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Ø (1)ChineseChemicalLetters杂志编委(中科院TOP1区，IF：8.445) Ø (2)FrontiersinCellularandInfectionMicrobiology(杂志客座主编) Ø (3)FrontiersinBioengineering and Biotechnology (杂志客座主编) Ø (4)中国人体修复技术和材料创新联盟专家委员会委员 | ||||||
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奖励与荣誉： |
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Ø （1）山东省泰山学者 青年专家 | ||||||
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主持或参与的项目： |
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(1) 国家自然科学基金委员会, 青年科学基金项目, 82003673, 新型多肽蛋白类药物纳米缓释载体的构建及性能调控机制研究, 2021-01-01 至 2023-12-31, 24万元, 在研, 主持 (2) 山东省委组织部, 山东省泰山学者青年项目, tsqn202211065, 海洋多肽类药物纳米制剂的开发与工程转化, 2022-07 至 2025-06, 75万元, 在研, 主持 (3) 海南省科技厅, 海南省自然科学基金, 2021JJLH0037, 海洋多肽类药物口服纳米制剂的开发, 2022-06-28至2025-06-28, 8 万元，在研，主持 (4) 国家自然科学基金委员会, 国际(地区)合作与交流项目, 51820105004, 蛋白类药物的聚合物输送材料及工程, 2019-01-01 至 2023-12-31, 246万元, 在研, 参与 (5) 国家自然科学基金委员会, 青年科学基金项目, 81801814, 工程化细胞外囊泡介导铂类前药-免疫检查点阻断剂纳米粒逆转顺铂耐药肿瘤的研究, 2019-01-01 至 2021-12-31, 21万元, 结题, 参与 | ||||||
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学术成果： |
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入职海大后：
16. Restoring cellular calcium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy) ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy.Jingwen Zhang, Jiahui Yan, Yanan Wang, Liangmin Yu*, Xuefeng Yan, Jun Wu*, Zhiyu He*.
Chinese Chemical Letters (2023）In Press，通讯作者IF：8.455 中科院TOP 1区
15. Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways. Jiahui Yan, Jingwen Zhang, Yanan Wang, Hong Liu, Xueping Sun, Liangmin Yu*, Xuefeng Yan, Zhiyu He*.
Advanced Science (2023）2207448，通讯作者. IF：17.521 中科院TOP 1区
14. Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment-Responsive BAPTA-AM/BAC Co-Delivery Nanosystem.
Jiahui Yan, Yanan Wang, Jingwen Zhang, Xiaohu Liu, Liangmin Yu, Zhiyu He*.
Small (2023）202206936, 通讯作者IF：15.153 中科院TOP 1区
13. 1,2-Bis(2-aminophenoxy)ethane‐N,N,N′,N′‐tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid-Bilirubin Nanoparticles for Acute Kidney Injury Therapy via Alleviating Calcium Overload Mediated Endoplasmic Reticulum Stress.Yanan Wang, Minju Pu, Jiahui Yan, Huichao Wei, Liangmin Yu*, Xuefeng Yan, Zhiyu He*
ACS Nano 17 (2023）472-491 通讯作者IF：18.027 中科院TOP 1区
12. The Advancement of Gas-Generating Nanoplatforms in Biomedical Fields: Current Frontiers and Future Perspectives.Jiahui Yan, Yanan Wang, Xinyu Song, Xuefeng Yan, Yi Zhao*, Liangmin Yu, Zhiyu He*.
Small Methods (2022) 2200139. 通讯作者 IF：15.367 中科院TOP 1区
11. Innovations and challenges of polyphenol-based smart drug delivery systems.Yanan Wang, Jingwen Zhang, Yi Zhao, Xinyu Song, Liangmin Yu*, Xuefeng Yan, Jun Wu*, Zhiyu He*.
Nano Research (2022) 通讯作者 IF: 10.269 中科院TOP 1区
10. Cell-Selective Encapsulation within Metal–Organic Framework Shells via Precursor-Functionalized Aptamer Identification for Whole-Cell Cancer Vaccine.Huihui Yang, Yanfei Zhang, Leli Zeng, Wen Yin, Yuzhi Xu*, Jun Chen, Siyang Liu*, Xiaoyong Zou, Zhiyu He, Zong Dai*.
Small Methods(2022) 2101391. 共同作者IF：15.367 中科院TOP 1区
9. Kinetic control of Phytic acid/Lixisenatide/Fe (III) ternary nanoparticles assembly process for sustained peptide release. Yanan Wang, Xinyu Song, Liwei Zhuang, Haifeng Lang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*.
International Journal of Pharmaceutics 611 (2021) 121317. 通讯作者 IF: 6.5 中科院TOP 2区
8. Dealing with MDR bacteria and biofilm in the post-antibiotic era: application of antimicrobial peptides-based nano-formulation.Xinyu Song, Pengyan Liu, Xiaohu Liu, Yanan Wang, Huichao Wei, Jingwen Zhang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*.
Materials Science and Engineering: C (2021) 112318. 通讯作者 IF: 8.457 中科院TOP 1区
7. Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications.
Yi Zhao, Minju Pu, Yanan Wang, Liangmin Yu*, Xinyu Song and Zhiyu He*.
Journal of Controlled Release 336 (2021) 233-251. 通讯作者 IF: 11.467 中科院TOP 1区
6. Recent advancements of nanomaterial-based therapeuti strategies toward sepsis: bacterial eradication, anti-inflammation and immunomodulation.Yi Zhao, Minju Pu, Jingwen Zhang, Yanan Wang, Xuefeng Yan, Liangmin Yu* and Zhiyu He*.
Nanoscale 13 (2021) 10726-10747. 通讯作者 IF: 8.307 中科院TOP 1区
5. Sustained Release Systems for Delivery of Therapeutic Peptide/Protein. Tianqi Nie, Wei Wang, Xiaohu Liu, Yanan Wang, Keyang Li, Xinyu Song, Jingwen Zhang, Liangmin Yu*, Zhiyu He*.Biomacromolecules 22, no. 6 (2021) 2299-2324. 通讯作者 IF: 6.998 中科院TOP 1区
4. Nanomaterial-based stategies in antimicrobial application：Progress and Perspectives. Yi Zhao, Long Chen, Yanan Wang, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*.
Nano Research(2021) 通讯作者IF: 10.269 中科院TOP 1区
3. Recent advances of nanomedicine-based strategies in diabetes and complications management：Diagnostics，monitoring，and therapeutics. Yanan Wang, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*.
Journal of Controlled Release 330 (2021) 618-640. 通讯作者 IF: 11.467 中科院TOP 1区
2. Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment of Parkinson’s disease.Tianqi Nie, Zhiyu He*, Jinchang Zhu, Kuntao Chen, Gregory P Howard, II Minn, Pengfei Zhao, Zaver M Bhujwalla, Hai-Quan Mao, Lixin Liu and Yongming Chen*.
Nano Research 14 (2021) 2749-2761 通讯作者 IF: 10.269 中科院TOP 1区
1. A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing.Lyu, Jingtong, Long Chen, Jiqiang Zhang, Xia Kang, Wenjie Wu, Hong Tang, Jun Wu*, Zhiyu He*, and Kanglai Tang*.
Biomaterials Science 8 (2020) 3649-3663. 通讯作者 IF: 7.59 中科院TOP 2区
